Important medicine
Obtain web page
Therapeutic motion
– Anticonvulsant
Indications
– Extreme pre-eclampsia: prevention of eclamptic seizures– Eclampsia: therapy of eclamptic seizures and prevention of recurrence
Kinds and strengths, route of administration – “1 ampoule magnesium sulphate”
– 5 g ampoule (0,5 g/ml, 10 ml) for IM injection or IV infusion
Dosage and period
– IV/IM protocol4 g by IV infusion in 100 ml of 0.9% sodium chloride over 15 to twenty minutes then, 10 g by IM route (5 g in every buttock) then, 5 g by IM route each 4 hours (altering buttock for every injection)
– IV protocol4 g by IV infusion in 100 ml of 0.9% sodium chloride over 15 to twenty minutes then 1 g per hour by steady IV infusion
Whatever the protocol chosen:– Proceed the therapy for twenty-four hours after the supply or the final seizure.– If seizures persist or recur, administer an additional 2 g (sufferers lower than 70 kg) to 4 g by IV infusion, with out exceeding 8 g complete dose through the first hour.
Contra-indications, adversarial results, precautions
– Cut back the dose in sufferers with renal impairment; don’t administer to sufferers with extreme renal impairment.– Could trigger:• ache on the injection web site, heat flushes; decreased fetal coronary heart fee;• in case of overdosage (hypermagnesaemia): – For the mom: diminished then absent patellar reflex (early signal), hypotension, drowsiness, confusion, problem in talking, bradycardia, respiratory despair (respiratory fee < 12/minute). - For the neonate: hypotonia, neurobehavioural impairment, apnoea, respiratory despair.– Don't mix with nifedipine.– Verify urine output each hour. Within the occasion of decreased urine output (< 30 ml/hour or 100 ml/4 hour), cease magnesium sulfate and carry out supply as quickly as doable. If supply can't be carried out instantly in a girl with eclampsia, cease magnesium sulfate for one hour then resume magnesium sulfate perfusion till supply.– Verify patellar reflex, blood stress, coronary heart and respiratory fee each quarter-hour through the first hour of therapy. If no indicators of overdosage are noticed, proceed this surveillance each hour. If indicators of overdosage are noticed: cease magnesium sulfate and provides 1 g calcium gluconate by gradual IV route as an antidote (on this occasion, seizures might recur).– Breast-feeding: no contra-indication