Truth is we’ve been delaying this article for a while until we had enough information & facts to allow us to enlighten our readers. Hopefully by the end of this article you’ll have no doubts about this subject.
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However, concerns are raised whether this approach might provoke diametrical (ie pro-oxidative) effects. The objective was to determine ascorbyl free radical (AFR) concentrations and potential variables of pro-oxidative damage. Design: Crossover study; six healthy males received daily infusions of 750 or 7500 mg vitamin C for six consecutive days.
Fasting concentrations of vitamin C and AFR were determined daily. Plasma concentrations of thiobarbituric acid-reactive substances (TBARS), tocopherol and urine concentrations of 8-oxoguanosine were determined on days 1 and 6. Vitamin C and AFR fasting concentrations on days 2-6 were slightly above the baseline, suggesting new, stable steady states.
Understanding Vitamin C Benefits
Vitamin C is a micronutrient with an array of benefits. Advertisement
Because the body doesn’t produce or store vitamin C, people need to include vitamin C in their diet every day. The recommended amount is about 75 to 90 milligrams a day for adults.
Most people turn to oranges or orange juice for their vitamin C, but other great sources include bell peppers, broccoli, tomatoes, kale, strawberries, lemons, mango and cantaloupe, reports Harvard Health. Most people think of vitamin C as an immunity booster, so they’ll load up on vitamin C during cold and flu season. Harvard Health explains that the most you can expect from taking a high dose of vitamin C is a shortened period of sickness (but only by about one day).
Vitamin C might also reduce a person’s risk of getting sick in extreme circumstances — as examples, Harvard Health lists skiers, marathon runners and soldiers working in sub-Arctic conditions.
Don’T Exceed The Recommended Dosage
This is because excessive supplemental vitamin C could be too much at one time, and your body can’t excrete it quickly enough. Chan School of Public Health states that people can take up to 3,000 milligrams before they start to see adverse symptoms.
Those who take megadoses of vitamin C might suffer diarrhea, nausea, heartburn, gastritis, fatigue, headaches and insomnia. As the National Institutes of Health explains, vitamin C deficiency is rare. Individuals who could benefit from getting more than the usual amount of vitamin C are people who smoke or who are exposed to secondhand smoke, people who eat a limited variety of food, and people with medical conditions such as malabsorption, types of cancer and kidney disease.
It’s important to note that if you’ve been trying to reap extra vitamin C benefits by taking supplements and are now ready to cut back, you should do so slowly.
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Ry (TBI) is one of the leading public health problems in the USA and worldwide. Despite efforts to prevent TBIs, the incidence continues to rise.
Inflammatory processes and oxidative stress play an important role in the pathomechanism of TBI and are exacerbated by impaired endogenous defense mechanisms, including depletion of antioxidants. As a reducing agent, free radical scavenger, and co-factor in numerous biosynthetic reactions, ascorbic acid (AA, vitamin C) is an essential nutrient that rapidly becomes depleted in states of critical illness. High-quality data on the effects of high-dose IV AA on TBI are lacking.
Historic data in a small number of patients demonstrate acute and profound AA deficiency in patients with central nervous system pathology, particularly TBI, and a strong correlation between low AA concentrations and poor outcomes. Whether this translates into improved clinical outcomes will depend on identifying the ideal target patient population and possible treatment combinations, factors that need to be evaluated in future clinical studies. With its excellent safety profile and low cost, high-dose IV AA is ready to be evaluated in the early treatment of TBI patients to mitigate secondary brain injury and improve outcome.