2Rheumatology Division, School Hospital Brno, Brno, Czech Republic
Summary
Introduction
Although inestimable assets have been devoted to growing many nonsteroidal anti-inflammatory brokers, scarce foreign money has been given to the notion that development of osteoarthritis could possibly be retarded by dietary merchandise [7, 11, 13, 14], though a number of studies and scientific trials are altering this case [8]. A number of current research have proven that orally administered enzymatic hydrolysed collagen (EHC) (Colatech®) is absorbed and distributed to joint tissues [11] and has analgesic and anti inflammatory properties [1, 2, 11, 16]. Nonsteroidal anti-inflammatory medicine (NSAIDs) are the most typical symptomatic therapy however have main adversarial results [3] and would possibly even worsen the osteoarthritis course of [7, 9, 13, 19].
Materials and strategies
Outcomes
The 2 therapy teams weren’t considerably totally different in demographic knowledge, e.g., intercourse, age, weight, peak, length of KOA, location of KOA, base-line knowledge, very important indicators, or poisonous habits . Thus, every group comprised 47 (within the EHC group) and 46 (within the GS group) completers. As a number of sufferers withdrew from the trial, the outcomes weren’t considerably affected, whether or not the statistical methodology was carried out by an ITT evaluation or evaluation on obtainable completers.
Dialogue
It may be argued that the Colatech® routine was 10 g qd, whereas the GS routine was 1.5 g qd, however it should be thought of that Colatech® isn’t a drug, however a meals. Althought Colatech® has demonstrated good efficacy in a number of earlier scientific trials [1, 2, 16], inducing enchancment of the joints and basic symptomatology akin to ache and stiffness, till now, it has by no means been demonstrated in a double-blind, randomised, comparative trial. It additionally proved a lot better than GS in bettering stiffness (p < 0.05), tin the WOMAC rating (p < 0.05), within the variety of affected joints (p < 0.05) and within the SF-36 Questionnaire (p < 0.05).
Conclusion
Colatech® has demonstrated to be environment friendly in bettering scientific standing in KOA sufferers, with vital enchancment in ache scores, practical joint standing and a greater high quality of life. Furthermore, the faster, though solely slight, onset of motion of Colatech®, in addition to an roughly equal charge of adversarial occasions to GS, would possibly signify an fascinating, ample and advantageous various and play an essential function within the administration of OA of the knee. It demonstrated clinically higher efficacy than GS after 2, 4, 8 and 12 weeks of therapy.