This article aims to clear any doubts and questions you may have about this subject and we will do our best to do so.
Evidence-Based Answer:
14 meta-analysis of 15 trials (quasi-random and RCT) with a total of 28,271 patients that compared the effect of vitamin D on fracture risk with placebo or no treatment, found no benefit for vitamin D supplementation (TABLE).1 Patients lived in community and nursing home settings and ranged in age from 50 to 85 years; 24% to 100% were female. Formulations of vitamin D included cholecalciferol (D 3 ) 400 to 2000 IU/d for 4 months to 5 years or 100,000 to 500,000 IU every 3 to 12 months for 1 to 5 years; calcifediol (25(OH)D 3 ) 600 IU/d for 4 years; and ergocalciferol (D 2 ) 400 IU/d for 2 years or 3000 to 300,000 IU every 3 to 12 months for 10 months to 3 years. Included patients were mostly by referral to tertiary or university hospitals and outpatient community settings.
Most of the studies included only a small number of patients (about 200), with the largest study having 740 patients. The age range was 50 to 77 years, and 50% to 100% were female. Study exclusions included osteomalacia, malabsorption, hyperparathyroidism, active kidney stones, history of hypercalciuria, cancer, incurable disease, dementia, severe chronic illness (renal or liver failure), recent stroke or fracture, and drugs that affect bone metabolis.
Abstract
In three out of four well-powered trials that used recommended doses of vitamin D 700–1000 IU per day, vitamin D supplementation did not significantly influence fracture risk. In one of these trials, a statistically significant fracture reduction was observed in nursing home residents having severe vitamin D deficiency, low calcium intake and good compliance. Thirteen meta-analyses were done, and 11 of these showed a significantly decreased fracture incidence in the supplemented groups.
Vitamin D alone was not effective, studies combining vitamin D and calcium showed inconsistent results. In conclusion, a vitamin D supplement of 800 IU per day in combination with calcium may decrease the incidence of non-vertebral fractures, especially in persons in the older age groups having low-baseline vitamin D status and low calcium intake and showing good compliance.
Answers (1)
For some reason I am getting acidity after taking calcium supplement.
188 Views v
Answers Like The Answers?
Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition.
Calcium And Vitamin D: A Partnership
Calcium and vitamin D is the dynamic duo that works together to strengthen and protect your bones. However, some people get adequate dietary calcium but are low in vitamin D.”.