Medically reviewed by Medication.com. Final up to date on Jan 7, 2021.
Scientific Overview
Restricted medical information can be found. The oral median deadly dose (LD50) of curcumin in rats and mice was larger than 2,000 mg/kg physique weight.
Scientific Household
Botany
The dried major bulb and secondary lateral rhizomes are collected, cleaned, boiled, and dried to be used in medicinal and meals preparations.1, 2, 3, 4, 5 The genus Curcuma L. might comprise greater than 100 species, with Curcuma longa L. in all probability one of the best recognized. Synonymous with Curcuma domestica Val, turmeric is a perennial plant discovered all through Southeast Asia, in addition to China, Australia, and the South Pacific.
Historical past
Within the conventional Ayurvedic medical system, turmeric is a well-recognized remedy for quite a few respiratory circumstances (eg, bronchial asthma, bronchial hyperactivity, allergic reactions), liver issues, anorexia, rheumatism, diabetic wounds, cough, and sinusitis.5, 6 Within the Indian subcontinent, turmeric is medicinally valued for its wound therapeutic properties. In conventional Chinese language drugs, turmeric is used to deal with circumstances that trigger stomach ache. Turmeric has anti-inflammatory exercise and was used to deal with sprains and swelling in historic Hindu drugs.5, 6
Chemistry
Different curcuminoids structurally associated to curcumin are additionally discovered within the extract and embrace demethoxy-curcumin and bis-demothoxy-curcumin. Curcumin modulates the Nrf2-keap1 pathway within the cell and binds to antioxidant responsive parts in DNA that scale back the reactive oxygen species. In contrast to most pure antioxidants that comprise beta-diketone or polyphenolic useful teams, curcumin possesses each lively moieties.
Makes use of and Pharmacology
Curcumin-phospholipid complicated (1 g/day; equal to 200 mg/day pure curcumin) supplementation resulted in a major discount within the imply vitamin E ranges in comparison with baseline (−0.12 micromol/L; P=0.004). Moreover the imply discount between the curcumin-phospholipid in addition to the curcumin (1 g/day) teams and controls was important (P=0.004 and P=0.005, respectively). A 6-week randomized managed trial investigated the impact of curcumin on serum vitamin E ranges in Iranian sufferers with metabolic syndrome (n=120).
Dosing
Dosages of three to six g/day have been investigated for protecting results towards ulcers.62, 63 Day by day oral doses of curcumin 3,600 mg have been advocated to be used in medical trials25 however dosages of as much as 8 g/day have been utilized in sufferers with superior pancreatic most cancers.10 A extremely absorbable colloidal nanoparticle formulation has been used at 1,800 mg/day for reminiscence enchancment and discount of amyloid deposition in non-demented adults.118 Larger doses are related to adversarial GI results.2 In a single examine, sufferers took one 500 mg capsule twice every day with or with out meals for 8 weeks for remedy of main depressive dysfunction.101 Powdered turmeric root has historically been used as a stimulant and carminative at dosages of 0.5 to three g/day.