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This research was performed to determine the effects of vitamin E supplementation on endometrial thickness, and gene expression of VEGF and inflammatory cytokines among women with implantation failure. Methods: A randomized clinical trial was done among 40 women with implantation failure aged 18-37 years old. Participants were randomly divided into two groups: group A (n = 20) received 400-IU vitamin E supplements and group B (n = 20) received placebo for 12 weeks.
Conclusions: Overall, vitamin E supplementation for 12 weeks among women with implantation failure had beneficial effects on endometrial thickness, MDA values, and gene expression of LDLR, IL-1, and TNF-.
Abstract
The etiology is unknown in 30-40%. However high uterine artery resistance is accounted as one of the recurrent abortion reasons.
Objective: The objective of the current study was to determine the impacts of vitamin E and aspirin on the uterine artery blood flow in women having recurrent abortions due to impaired uterine blood flow. Results: All drug regimens caused an enhancement in uterine perfusion with a significant decline in uterine artery PI value. Conclusion: Vitamin E, aspirin and especially their combination are effective in improving uterine artery blood flow in women with recurrent abortion due to impaired uterine blood flow.
More well-designed studies are needed to find out whether the enhancement of uterine perfusion may lead to a better pregnancy outcome. Key Words: Recurrent abortion, Aspirin, Vitamin E, Pulsatility index.
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) were identified with unfavorable endometrial lining by thickness ≤6 mm or echogenicity type ≥2 in late follicular phase.
These parameters were unresponsive to high dose oral & vaginal estradiol (E2) therapy. Outcome measures: endometrial thickness, echogenicity type and pregnancy. Conclusions
In our case series, PTX and Vitamin E were used for patients who failed to develop an adequate uterine lining.
Middle East Fertility Society Journal
These approaches comprising hormonal management by estradiol, tamoxifen, human chorionic gonadotropin (hCG) and gonadotropin-releasing hormone (GnRH) agonist, vasoactive agents such as aspirin, vitamin E, pentoxifylline, nitroglycerin and sildenafil, intra-uterine infusion of growth factor such as Granulocyte Colony Stimulating Factor (G-CSF) and the latest application of platelet-rich plasma, electrical stimulation, regenerative medicine and presentation of endometrial receptivity array. In spite of the large variety of treatment, most of the choices achieve only minor modification in the endometrium thickness and have not been validated so far.