Vitamins 696x496 1

Vitamin K Antagonist

This blog post will walk you through: vitamin k antagonist.

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Venous thromboembolism, pulmonary embolism, thromboembolism with atrial fibrillation, thromboembolism with cardiac valve replacement, and thromboembolic events post myocardial infarction. Dicoumarol For decreasing blood clotting. Often used along with heparin for treatment of deep vein thrombosis.
Phenindione For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Phenprocoumon An anticoagulant drug used for the prevention of thrombosis. Acenocoumarol An anticoagulant drug used in the prevention of thromboembolic diseases in infarction and transient ischemic attacks, as well as management of deep vein thrombosis and myocardial infarction.
Ethyl biscoumacetate Ethyl biscoumacetate is a courmarin that is used as an anticoagulant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p226)

Fluindione Fluindione is under investigation for the treatment of Venous Thrombosis, Pulmonary Embolism, Permanent Atrial Fibrillation, and Anticoagulating Treatment on a Duration at Least 12-month-old Superior. Fluindione has been investigated for…

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Clorindione Clorindione is a vitamin K antagonist, which may be useful to decrease prothrombin levels in humans.
S-warfarin is 2-5 times more potent than the R-isomer in…

(S)-Warfarin Warfarin consists of a racemic mixture of two active enantiomers—R- and S- forms—each of which is cleared by different pathways. S-warfarin is 2-5 times more potent than the R-isomer in.

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In the past 5 years, four new agents-the direct factor Xa inhibitors apixaban, edoxaban and rivaroxaban and the direct thrombin inhibitor dabigatran [collectively known as direct oral anticoagulants (DOACs) or non-VKA oral anticoagulants]-have been approved for these and other indications.
Currently available real-world evidence shows that DOACs have similar or improved effectiveness and safety outcomes compared with warfarin. Treatment decisions on which DOAC is best suited for which patient to maximize safety and effectiveness should take into account not only clinically relevant patient characteristics but also patient preference. This article reviews and highlights real and perceived implications of VKAs for the prevention of stroke in patients with non-valvular AF, with specific reference to their strengths and weaknesses compared with DOAC.

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He is drowsy with signs of a left hemiparesis. He has a history of atrial fibrillation, and he has been taking warfarin (INR target 2-3) for several years. Warfarin is a vitamin K antagonist (fig 1) and a coumarin (more accurately 4-hydroxycoumarin) derivative.
In some countries, other coumarins are used with a similar action but a shorter (acenocoumarol) or longer (phenprocoumon) half-lif.

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