Vitamin D3 Safety

If you’re here, then you probably Google’d: vitamin d3 safety. This subject along with many others are quite common.

Save Citation To File

Therefore, the Institute of Medicine has set the UL for adults at 100 μg/d, and the adequate circulating 25(OH)D level at 50 to 125 nmol/l. In clinical practice, oral vitamin D dosing has to consider that the increment in circulating 25(OH)D depends on baseline 25(OH)D levels and the person’s body weight. It is reasonable to assess 25(OH)D before and 3-6 months after initiation of oral vitamin D administration and to adjust the dose, if necessary.

In Future, Two Issues Have To Be Clarified: First, Would It Be More Appropriate To Define Instead Of A Fixed Ul A Variable Ul, Based On The Individual’S Body Weight?

Second, what are the underlying mechanisms, if any, for potentially harmful vitamin D effects at circulating 25(OH)D levels between 125 and 375 nmol/.

Recent Blog Articles

Ing too much vitamin D can cloud its benefits and create health risks

December 15, 2019

Disclaimer:

As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles.
No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinicia.

Abstract

Objective: Our objective was to assess the efficacy and safety of prolonged vitamin D 3 intakes of 25 and 100 μg (1000 and 4000 IU)/d. Efficacy was based on the lowest serum 25-hydroxyvitamin D [25(OH)D] concentration achieved by subjects taking vitamin D 3 ; potential toxicity was monitored by measuring serum calcium concentrations and by calculating urinary calcium-creatinine ratios.
Serum 25(OH)D was measured by radioimmunoassay. Serum calcium and urinary calcium excretion did not change significantly at either dosage during the study. Conclusions: The 100-μg/d dosage of vitamin D 3 effectively increased 25(OH)D to high-normal concentrations in practically all adults and serum 25(OH)D remained within the physiologic range; therefore, we consider 100 μg vitamin D 3 /d to be a safe intake.

Chapter And Author Info

We review the alternatives of vitamin D supplementation through dietary, other natural supplements as well as sunlight therapy, in an evidence-based manner.

Leave a Comment