This blog post will walk you through: vitamin e succinate. Don’t worry, we’ve got all the answers about this subject.
International Journal Of Pharmaceutics
More importantly, the mitochondrial targeting and damaging property of VES endows it with great potential in exhibiting synergetic effect with conventional chemotherapeutic drugs and overcoming multidrug resistance (MDR). Given the lipophilicity of VES that hinders its bioavailability and therapeutic activity, nanotechnology with multiple advantages has been widely explored to deliver VES and opened up new avenues for its in vivo application. This review aims to introduce the anticancer mechanisms of VES and summarize its delivery strategies using nano-drug delivery systems.
Specifically, VES-based combination therapy for synergetic anticancer effect, MDR-reversal, and oral chemotherapy improvement are highlighted.
Save Citation To File
And is converted to the redox-active α-TOH (B) (adapted from Weber et al, 2002). In the end, the tumour size was estimated (A) and the mouse plasma was analysed for the level of α-TOH (B).
(C) Bases of the hypothesis are presented in this communication. After reaching the circulation, a VE analogue (epitomised in our studies by α-TOS) binds to circulating lipoproteins (LP), which carry it to the microvasculature, where it kills cancer cells (this is the ‘provitamin E effect’). Lipoproteins with bound α-TOS are cleared in the liver, where nonspecific esterase (NE) very efficiently cleaves it into α-TOH.
Side Effects
Uct by mouth as directed. Follow all directions on the product package. If your liquid form is a suspension, shake the bottle well before each dose.
Dosage is based on your medical condition and response to treatment. Taking too much vitamin E may increase your risk of side effects. There is no proof that high doses of vitamin E help to prevent or treat heart disease.
In some people, taking these high doses may even be harmful. Talk to your doctor or pharmacist and discuss the risks and benefits before taking vitamin E supplements. To help you remember, take it at the same time each day.
If your condition persists or worsens, or if you think you may have a serious medical problem, seek immediate medical attentio.
D-Α-Tocopherol Polyethylene Glycol 1000 Succinate
on potency, density and molecular wt.