What does CK7 test for? CK7 distinguishes between lung and breast epithelium that stain positive, and colon and prostate epithelial cells that are negative. It also reacts with many benign and malignant epithelial lesions, e.g. adenocarcinomas of the ovary, breast and lung.
What is CK20 in cancer? In daily practice, the phenotype CK20−/CK7− is used to clarify the diagnosis of hepatocellular carcinoma, renal cell carcinoma, prostate carcinoma, squamous cell and small cell lung cancer as well as head and neck carcinoma.
What is CK20 in cancer? CK20 is a 46-kDa LMW keratin that was discovered by Moll and associates. 137. The tissue distribution of CK20 is limited predominantly to GI epithelium and its tumors, mucinous tumors of the ovary, and Merkel cell neoplasms.
Related Questions
What is CK7 negative CK20 negative?
For example, a CK7-negative/CK20-positive phenotype is often associated with carcinomas of colorectal origin, whereas a CK7-positive/CK20-negative phenotype is seen in a wide variety of carcinomas, including carcinomas of the lung, breast, thyroid, pancreas, and female genital tract.
Is keratin positive or negative?
The spindle cells are usually positive for keratin AE1/E3 and CD10, and can be positive for keratin 7, keratin 20, and EMA, with a variable number of cells expressing these markers. These cells can also express muscle actin, smooth-muscle actin, h-caldesmon, and desmin, but they are negative for S-100.
What is CK7 negative CK20 negative?
For example, a CK7-negative/CK20-positive phenotype is often associated with carcinomas of colorectal origin, whereas a CK7-positive/CK20-negative phenotype is seen in a wide variety of carcinomas, including carcinomas of the lung, breast, thyroid, pancreas, and female genital tract.
What is CK7 and CK20?
CK7 is found in the glandular epithelium and epithelial tumors of lung, ovary, endometrium and breast, but is not found in GI epithelium. Conversely, CK20 is expressed principally in the normal glands and epithelial tumors of the GI tract, urothelium, and Merkel cells.23 janv.
What is CK20 in cancer?
In daily practice, the phenotype CK20−/CK7− is used to clarify the diagnosis of hepatocellular carcinoma, renal cell carcinoma, prostate carcinoma, squamous cell and small cell lung cancer as well as head and neck carcinoma.27 jui.
What does cytokeratin 7 positive mean?
Positive for CK7 means that immunohistochemistry was performed and CK7 protein was seen inside the cells of interest in the tissue sample. Reactive is another term that pathologists use to describe cells that are producing CK7.
What is CK7 and CK20 negative?
CK7 is present in various ductal and glandular epithelia, including the lung, breast, skin appendages, salivary gland, pancreas, ovary, and endometrium. CK20 is widely expressed in mucosal cells of the gastrointestinal and urinary tract.
What is CK20 in cancer?
In daily practice, the phenotype CK20−/CK7− is used to clarify the diagnosis of hepatocellular carcinoma, renal cell carcinoma, prostate carcinoma, squamous cell and small cell lung cancer as well as head and neck carcinoma.
What does CK7 negative mean?
Negative for CK7 means that immunohistochemistry was performed and CK7 protein was not seen inside the cells of interest in the tissue sample. Non-reactive is another term that pathologists use to describe cells that are not producing CK7.
What CK20 negative?
Negative for CK20 means that the CK20 protein was not seen inside the cells of interest in the tissue sample. Non-reactive is another term that pathologists use to describe cells that are not producing CK20.
What does Pan cytokeratin positive mean?
Background: Cytokeratins are specific markers of epithelial cancer cells in bone marrow. We assessed the influence of cytokeratin-positive micrometastases in the bone marrow on the prognosis of women with breast cancer.
What does negative for CK20 mean?
Negative for CK20 means that the CK20 protein was not seen inside the cells of interest in the tissue sample. Non-reactive is another term that pathologists use to describe cells that are not producing CK20.
What is CK7 positive CK20 positive?
For example, a CK7-negative/CK20-positive phenotype is often associated with carcinomas of colorectal origin, whereas a CK7-positive/CK20-negative phenotype is seen in a wide variety of carcinomas, including carcinomas of the lung, breast, thyroid, pancreas, and female genital tract.