Collagen can be considerable in corneas, blood vessels, the intestine, intervertebral discs, and the dentin in enamel.[3] In muscle tissue, it serves as a significant part of the endomysium. Collagen constitutes one to 2 p.c of muscle tissue and accounts for six% of the burden of sturdy, tendinous muscle tissues.[4] The fibroblast is the commonest cell that creates collagen. Relying upon the diploma of mineralization, collagen tissues could also be inflexible (bone) or compliant (tendon) or have a gradient from inflexible to compliant (cartilage).
(*5*)Contents
(*5*)Etymology[edit]
The title collagen comes from the Greek κόλλα (kólla), that means “glue”, and suffix -γέν, -gen, denoting “producing”.[6][7]
(*5*)Human varieties[edit]
The 5 most typical varieties are:[11]
(*5*)Medical makes use of[edit]
All through the 4 phases of wound therapeutic, collagen performs the next features in wound therapeutic:
(*5*)Primary analysis[edit]
Collagen is utilized in laboratory research for cell tradition, finding out cell conduct and mobile interactions with the extracellular atmosphere.[25]
(*5*)Biology[edit]
The most typical motifs within the amino acid sequence of collagen are glycine-proline-X and glycine-X-hydroxyproline, the place X is any amino acid aside from glycine, proline or hydroxyproline. The collagen protein consists of a triple helix, which typically consists of two similar chains (α1) and a further chain that differs barely in its chemical composition (α2).[26] The amino acid composition of collagen is atypical for proteins, significantly with respect to its excessive hydroxyproline content material. The typical amino acid composition for fish and mammal pores and skin is given.[27]
(*5*)Synthesis[edit]
Many micro organism and viruses secrete virulence components, such because the enzyme collagenase, which destroys collagen or interferes with its manufacturing.