Medically reviewed by Medicine.com. Final up to date on April 9, 2021.
Regular Grownup Dose for Hypomagnesemia
1 gram IM each 6 hours for 4 doses (gentle hypomagnesemia) or as a lot as 250 mg/kg IM inside a 4-hour interval (extreme hypomagnesemia)
OR
5 grams in 1 liter of applicable diluent IV over 3 hours
-Don’t exceed IV infusion charge of 150 mg/minute
Feedback:
-Applicable diluents embody 5% dextrose or 0.9% sodium chloride.
-Use warning to forestall exceeding renal excretory capability.
-Could also be given undiluted intramuscularly.
-Rigorously alter dosage to particular person necessities and response.
-Discontinue as quickly as the specified impact is obtained.
Regular Grownup Dose for Atrial Tachycardia
3 to 4 grams (30 to 40 mL of a ten% answer) IV over 30 seconds
Feedback:
-Use with EXTREME CAUTION.
-Use provided that easier strategies have failed and there’s no proof of myocardial injury.
Use: Paroxysmal atrial tachycardia
Regular Grownup Dose for Pre-eclampsia/Eclampsia
Extreme pre-eclampsia or eclampsia:
Preliminary dose: 4 to five grams IV in 250 mL of applicable diluent, with simultaneous IM administration of as much as 5 grams (10 mL undiluted answer) in EACH buttock; complete dose: 10 to 14 grams
-Preliminary IV dose of 4 grams may be diluted to a ten% or 20% answer and injected IV over 3 to 4 minutes
Upkeep dose: 4 to five grams IM into alternate buttocks each 4 hours as wanted
OR
Upkeep dose: 1 to 2 grams/hour IV by fixed infusion
-Proceed remedy till paroxysms stop
Most dose: 30 to 40 grams/day
Feedback:
-Applicable diluents embody 5% dextrose or 0.9% sodium chloride.
-A serum magnesium stage of 6 mg/100 mL is taken into account optimum for seizure management.
-The necessity to proceed remedy relies on the persevering with presence of patellar reflex and sufficient respiratory operate.
-Steady maternal administration past 5 to 7 days may cause fetal abnormalities.
-Monitor serum magnesium and affected person medical standing to keep away from overdosage.
-Medical indications of a secure dose embody presence of patellar reflex (knee jerk) and absence of respiratory despair (about 16 breaths/minute or extra).
-Check patellar reflex earlier than repeat doses and don’t administer magnesium if absent.
-Deep tendon reflexes start to decrease at magnesium ranges above 4 mEq/L.
-Reflexes could also be absent at 10 mEq/L, the place there may be potential for respiratory paralysis.
-An injectable calcium salt needs to be instantly out there to counteract magnesium intoxication.
Makes use of: Prevention and management of seizures in pre-eclampsia and eclampsia
Regular Grownup Dose for Constipation
2 to 4 stage teaspoons dissolved in 8 ounces water orally
-Repeat dose in 4 hours if wanted.
Most dose: 2 doses per day
Makes use of: Cathartic or laxative
Regular Grownup Dose for Barium Poisoning – “magnesium sulfate dosage”
1 to 2 grams IV
-Don’t exceed IV infusion charge of 150 mg/minute
Use: To counteract the muscle-stimulating results of barium poisoning
Regular Grownup Dose for Seizures
1 gram intramuscularly or IV
-Don’t exceed IV infusion charge of 150 mg/minute
Use: Seizures related to epilepsy, glomerulonephritis, or hypothyroidism
Regular Grownup Dose for Cerebral Edema
2.5 grams (25 mL of a ten% answer) IV
-Don’t exceed IV infusion charge of 150 mg/minute
Use: Discount of cerebral edema