Medically reviewed by Medication.com. Final up to date on Sep 5, 2020.
Pronunciation
(magazine NEE zhum GLOO koe nate)
Dosage Kinds
Excipient info offered when accessible (restricted, significantly for generics); seek the advice of particular product labeling. [DSC] = Discontinued product
Pill, Oral:
Magazine-G: 500 mg (27 mg elemental magnesium)
Magonate: 500 mg (27 mg elemental magnesium) [DSC] [contains fd&c yellow #6 aluminum lake]
Generic: Elemental magnesium 27.5 mg
Pill, Oral [preservative free]:
Generic: 500 mg (27 mg elemental magnesium)
Model Names: U.S.
Pharmacologic Class
Pharmacology – “magnesium 27 mg”
Magnesium is vital as a cofactor in lots of enzymatic reactions within the physique involving protein synthesis and carbohydrate metabolism (no less than 300 enzymatic reactions require magnesium). Actions on lipoprotein lipase have been discovered to be vital in decreasing serum ldl cholesterol and on sodium/potassium ATPase in selling polarization (eg, neuromuscular functioning).
Absorption
Oral: Inversely proportional to quantity ingested; 40% to 60% beneath managed dietary circumstances; 15% to 36% at greater doses
Distribution
Bone (50% to 60%); extracellular fluid (1% to 2%)
Excretion
Urine (as magnesium); feces (as unabsorbed drug)
Protein Binding
30%, to albumin
Use: Labeled Indications
Dietary complement: Dietary magnesium complement
Contraindications
Hypersensitivity to any element of the formulation