1Department of Biochemistry, Ataturk College College of Drugs, Erzurum Turkey
1Department of Biochemistry, Ataturk College College of Drugs, Erzurum Turkey
1Department of Biochemistry, Ataturk College College of Drugs, Erzurum Turkey
1Department of Biochemistry, Ataturk College College of Drugs, Erzurum Turkey
2Polyclinic of Paediatric Gastroenterology, Hepatology and Diet, Denizli State Hospital, Denizli, Turkey
1Department of Biochemistry, Ataturk College College of Drugs, Erzurum Turkey
1Department of Biochemistry, Ataturk College College of Drugs, Erzurum Turkey
Summary
Özet
Amaç:
Helicobacter pylori enfeksiyonu mikro besin eksikliklerinin eşlik ettiği hafif şiddetten ağır tablolara kadar değişebilen hastalıklara sebep olabilir. Biz bu çalışmada Helicobacter pylori pozitif çocuklarda serum çinko, bakır, magnezyum ve selenyum düzeylerini araştırılmayı amaçladık.
Gereç ve Yöntem:
Kronik karın ağrısı olan ve Helicobacter pylori pozitifliği saptanan otuz dört hasta çocuk ve hasta grubu ile aynı demografik özelliklere sahip sağlıklı 20 çocuk çalışmaya dahil edildi. Serum çinko, bakır ve magnezyum düzeyleri atomik absorpsiyon spektrofotometresi alev ünitesinde, serum selenyum seviyeleri ise aynı spektrofotometrenin grafit fırın ünitesinde ölçüldü.
Bulgular: – “magnesium h pylori”
Çalışmamız sonucunda Helicobacter pylori pozitifliği saptanan çocuklarda kontrol grubuna göre serum çinko düzeylerini istatistiksel olarak anlamlı de-recede yüksek, Magnezyum düzeylerini ise düşük bulduk (p<0,05). Bakır düzeyleri kontrol grubunda daha yüksek olmasına rağmen istatistiksel olarak anlamlı değildi (p>0,05). Serum selenyum düzeyleri açısından her iki grup arasında istatistiksel anlamlı bir farklılık yoktu.
Sonuç:
Helicobacter pylori pozitif çocuklarda, birçok eser component ve mineral metabolizmasında değişiklikler olabileceğini söyleyebiliriz.
Introduction
Helicobacter pylori (H. pylori) are estimated to contaminate not less than half of world inhabitants. The incidence of H. pylori an infection in kids is about 10% in developed nations and varies from 80 to 100% in creating nations [1]. H. pylori an infection in gastric mucosa could also be asymptomatic transporter or could also be associated to completely different conditions from reasonable gastritis to extreme illnesses reminiscent of gastric most cancers [2]. Though extreme medical signs of this an infection are represented in adults, epidemiological research present that the an infection is acquired in childhood [3, 4].
Since this childhood an infection has the potential of worsening the grownup illness and effecting micronutrient metabolism [5], the significance of stopping, treating, and following-up the an infection in childhood has arisen [3].
H. pylori an infection impacts the digestion and absorption of dietary vitamins by disrupting gastric secretion and acidification features. Accordingly, deficiencies in micro-nutrients reminiscent of hint parts and minerals, brought on by this an infection, might set off impairments in organic and immunological features [6].
Zinc is a necessary hint component present in all physique fluids and tissues. It has features in development and improvement in addition to in lots of metabolic occasions like immunological mechanisms and protein synthesis. Thus zinc is a obligatory nutrient in animals. Physiological stresses, reminiscent of trauma, infections, and low protein consumption, trigger a lower within the plasma zinc stage. Copper is a element of many enzymes within the physique, and these enzymes participate in varied metabolisms like collagen, elastin, melanin and catecholamine syntheses. Copper deficiency as a result of food plan is uncommon besides in malnutrition and in kids with power diarrhoea. Magnesium is a macro-mineral that has features in sustaining regular nerve-muscle transmission and replication, transcription and translation. Selenium, as within the type of selenocysteine, is concerned in glutathione peroxidase, iodothyronine de-iodinase, and thioredoxin reductase enzymes [7].
A number of research have proven that H. pylori an infection has relations to the deficiencies in copper, vitamin B12, folic acid, and vitamin A, C, and E [5, 8–11]. These deficiencies could also be derived from anorexia brought on by dyspeptic signs or from malabsorbtion secondary to intestinal bacterial infections, which is the results of hypo-achlorhydria within the abdomen within the presence of H. pylori.
Varied circumstances starting from gentle to extreme medical situations could also be accompanied by micronutrient deficiencies brought on by H. pylori an infection. Accordingly, we aimed on this research to research the serum zinc, copper, magnesium and selenium ranges in H. pylori optimistic kids.