1Department of Histology and Embryology, Medical College of Warsaw, Poland
Summary
Introduction
Curcumin could also be used as a preventive and healing agent in lots of illnesses, similar to neurodegenerative illnesses (together with Alzheimer’s illness), diabetes, most cancers, rheumatoid illnesses, atherosclerosis, pulmonary infective illness, persistent intestinal irritation, allergy, bronchial asthma, autoimmune illnesses, AIDS, psoriasis, and others [12]. Its effectiveness was additionally proved for main eye illnesses. We give attention to this topic afterward within the article.
Illnesses of the cornea
Conjunctivitis
Ophthacare, which comprises eight totally different herbs together with 1.30% w/v of Curcuma longa (rhizome), was reported to be efficient within the remedy of conjunctivitis, conjunctival xerosis (dry eye) and protected in varied infective and inflammatory conjunctival illnesses [63].
Curcuma longa referred to as haridra in India and in tropical areas is obtainable as Haridra Eye Drops. A medical research demonstrated the effectiveness of Haridra Eye Drops in treating bacterial conjunctivitis.
Pterygium
Curcumin at a dose of 20-80 μmol/l elevated the expression of spreading cell nuclear antigen, inhibited the proliferation and triggered the mobile demise of human pterygium fibroblasts in a dose- and time-dependent method. A pterygium is a progress of the conjunctiva or mucous membrane forming fibrous tissue in a triangular form that covers the white a part of the attention over the cornea. Ophthacare remedy of pterygium additionally confirmed constructive results in a research by Biswas et al.
Anterior uveitis
A helpful impact of Meriva (Indena, Milano, Italy), curcumin formulated with phosphatidylcholine, which improves bioavailability at the very least 10-fold as in comparison with the usual preparation, was noticed within the adjunct remedy of recurrent anterior uveitis of varied etiologies [66]. One other research of a standardized aqueous extract of Curcuma longa utilized topically led to the inhibition of E. coli lipopolysaccharide-induced anterior uveitis in rats and rabbits by lowering TNF-α exercise [67]. Its helpful results could stem from their antioxidative, anti-inflammatory, in addition to antifibrinolytic properties.
Glaucoma
Mfn2 suppression and Nrf2 elevation have been noticed after pretreatment with curcumin indicating that curcumin could alleviate retinal I/R harm by regulating the antioxidant system and should restore regular mitochondrial operate [71]. Nuclear issue erythroid 2-related issue 2 (Nrf2) exerts a protecting impact in opposition to oxidative stress and is elevated after retinal I/R harm. One of many animal fashions for open-angle glaucoma is acute retinal ischemia induced by excessive intraocular stress adopted by reperfusion (I/R).