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Tween iron deficiency and vitamin B12 and folate was recognized several decades ago. Combined deficiency is important in clinical practice owing to its relationship with malabsorption syndromes. Methods: A cohort of 35 young adult women with IDA was treated with oral iron.
Changes in serum vitamin B12, serum folate and other biochemical parameters were monitored. Results: Treatment with iron increased significantly serum folate and vitamin B12 from baseline. Conclusions: Data from our work suggest that iron deficiency could affect many metabolic pathways, including vitamin B12, folate and lipids.
These changes normalize after iron therapy, even in women with baseline low levels of serum vitamin B12. Healthcare practitioners should be aware of these changes in IDA management.
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Deficiency of either one results in anaemia, which is characterised by low haemoglobin concentration.
Symptoms result from reduced tissue oxygenation and include weakness, lethargy, palpitation, headache and shortness of breath. The first-time laboratory test of all patients suspected of being anaemic is the full blood count.
Medicine
Tamin B 12 and folate are required for essential metabolic functions.
Clinically, they present with not only disordered haematopoiesis, but also widespread effects in other organs that can precede the appearance of haematological abnormalities. Investigation of suspected iron, vitamin B 12 or folate deficiency should first be directed at establishing that the deficiency state exists, but this can be challenging because of the limitations of available biomarkers for evaluating tissue status. A careful assessment of clinical symptoms and signs is indispensable to guide appropriate requesting and interpretation of relevant laboratory tests.
Correcting the deficiency with supplements is usually straightforward, provided adherence to treatment is ensured.
Side Effects
Take this medication by mouth, usually once daily or as directed by your doctor. This medication is best taken on an empty stomach 1 hour before or 2 hours after meals.
Avoid taking antacids, dairy products, tea, or coffee within 2 hours before or after this medication because they will decrease its effectiveness. Do not lie down for at least 10 minutes after taking this medication. Do not use a household spoon because you may not get the correct dose.
If your liquid form is to be given by dropper, the dose may be placed well back on the tongue and followed with water or juice. Do not crush or chew the capsules. Doing so can release all of the drug at once, increasing the risk of side effects.
Use this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time each da.