The features of collagen XXIII are nonetheless unknown, though it’s believed that they may very well be just like different transmembrane proteins, comparable to collagen XIII.
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Discovery[edit]
Collagen XXIII was first recognized and remoted from rat prostate carcinoma cells by Jacqueline Banyard, Lere Bao and Bruce R. Zetter in 2003.[6]
Moreover, mobile localization of collagen XXIII was decided by immunofluorescence staining, utilizing an antibody that acknowledges the carboxyl terminus of the protein. They concluded that on the nucleotide degree, human and rat collagen XXIII alpha 1 present 76% identification.
Construction[edit]
In case that these molecules lose the lipid raft safety (i.e. when membrane levels of cholesterol lower) furin proteases can act, cleaving the protein proper exterior the cell, releasing the shed type of collagen XXIII on to the extracellular matrix.
Interplay with integrin α2β1[edit]
Collagen XXIII interacts in an ion-and conformation-dependent method with integrin α2β1.[9]
Integrin α2β1 is a collagen-binding integrin current on the dermis, due to this fact that is the placement the place the interplay takes place. Mobile receptors for collagens belong to the household of β1 integrins. Each proteins co-localize on basal keratinocytes floor.
Medical significance[edit]
Collagen XXIII performs a job as a biomarker for detection and recurrence of NCLSC cells (non-small cell lung carcinoma)[10] and the reappearance of prostate most cancers.[11] Some experiments counsel that collagen XXIII influences mobile adhesion and stimulates metastasis growth[12] by facilitating most cancers cells progress and survival when they’re rounded and never capable of unfold.
It has been proven that lack of collagen XXIII could complicate mobile adhesion and scale back lung most cancers cell retention.