Contents
Introduction
It is likely one of the most plentiful proteins current in mammals and it’s chargeable for performing a wide range of necessary organic features. It’s current in massive portions in connective tissue and gives tendons and ligaments with tensile power and pores and skin with elasticity. It typically works in conjuction with different necessary proteins comparable to keratin and elastin.
Biosynthesis
Peptide subunits of ~250 residues are assembled on the ribosome and are linked by carbohydrate residues to type α-chains [1]. Through the technique of collagen synthesis, free-hydroxyproline and hydroxylysine peptides seem as by-products, a few of that are metabolized and will seem in urine [1]. Three α-chains then affiliate with one another after which additional affiliate extracelluarly forming a molecule with a molecular weight of 360,000 [1].
Molecular Structure
These three α-chains are then twisted round each other in a rope-like method to supply the general tightly packed triple-helical type of the molecule. The interplay of α-chains is stabilized by way of interchain hydrogen bonding making the molecule pretty proof against assault by different molcules. This hydrogen bonding happens when the amino group (NH) of a glycine residue varieties a peptide bond with the carbonyl (C=0) of an adjoining residue.
Operate
There are near 30 several types of collagen which were recognized thus far.[5].
Essentially the most considerable kind of collagen current within the human physique is that of Sort I [5] with vital quantities of Sort II,III and IV additionally accounted for.
Collagen-Associated Problems
-more generally often called Brittle Bone illness