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Significance Assertion
Thus, GD1a might probably be used as a novel remyelinating compound or as mixture remedy along side different medication to boost totally different levels of remyelination in MS. The extracellular matrix (ECM) is considerably altered in continual MS lesions, which is believed to be an necessary remyelination-inhibiting issue. Exogenous ganglioside GD1a was demonstrated to beat the remyelination-inhibiting results of aggregated fibronectin throughout later levels of oligodendrocyte maturation.
Footnotes
References
Synthesis
The sentence in web page 1 stating that the remyelinating compounds “have progressed into clinical trials but only limited success has been achieved” is deceptive because it leaves the impression that these compounds have been examined in MS. It must be clarified that these are very early trials and MS trials are nonetheless ongoing. The remyelinating compounds haven’t been examined but in MS.