Collagen IV (ColIV or Col4) is a kind of collagen discovered primarily within the basal lamina. The collagen IV C4 area on the C-terminus will not be eliminated in post-translational processing, and the fibers hyperlink head-to-head, relatively than in parallel. Additionally, collagen IV lacks the common glycine in each third residue vital for the tight, collagen helix. This makes the general association extra sloppy with kinks. These two options trigger the collagen to kind in a sheet, the type of the basal lamina. Collagen IV is the extra frequent utilization, versus the older terminology of “type-IV collagen”.[citation needed] Collagen IV exists in all metazoan phyla.[1]
There are six human genes related to it:[2]
Medical significance [ edit ]
The alpha-3 subunit (COL4A3) of collagen IV is regarded as the antigen implicated in Goodpasture syndrome, whereby the immune system assaults the basement membranes of the glomeruli and the alveoli upon the antigenic website on the alpha-3 subunit turns into unsequestered as a consequence of environmental exposures.
Goodpasture syndrome presents with nephritic syndrome and hemoptysis. Microscopic analysis of biopsied renal tissue will reveal linear deposits of Immunoglobulin G by immunofluorescence. That is classically in younger grownup males.
Mutations to the genes coding for collagen IV result in Alport syndrome. This can trigger thinning and splitting of the glomerular basement membrane. It’ll current as remoted hematuria, sensorineural listening to loss, and ocular disturbances and is handed on genetically, often in an X-linked method, though there are rarer autosomal kinds.
Liver fibrosis and cirrhosis are related to the deposition of collagen IV within the liver. Serum Collagen IV concentrations correlate with hepatic tissue ranges of collagen IV in topics with alcoholic liver illness and hepatitis C and fall following profitable remedy.[3][4]
Elevated glomerular and mesangial deposition of collagen IV happens in diabetic nephropathy and elevated urinary ranges are related to the extent of renal damage.[5]
References [ edit ]
^ Boute, Nicolas; Exposito, Jean-Yves; Boury-Esnault, Nicole; Vacelet, Jean; Noro, Nobuhiro; Miyazaki, Koyomi; Yoshizato, Katsutoshi; Garrone, Robert (1996). “Type IV collagen in sponges, the missing link in basement membrane ubiquity”. Biology of the Cell. 88 (1–2): 37–44. doi:10.1016/S0248-4900(97)86829-3. PMID 9175266. ^ Khoshnoodi, Jamshid; Pedchenko, Vadim; Hudson, Billy G (2008). “Mammalian collagen IV”. Microscopy Analysis and Method. 71 (5): 357–70. doi:10.1002/jemt.20564. PMC 4788096 PMID 18219669. ^ Tsutsumi, Mikihiro; Takase, Shujiro; Urashima, Sachio; Ueshima, Yasuhiro; Kawahara, Hiromu; Takada, Akira (1996). “Serum Markers for Hepatic Fibrosis in Alcoholic Liver Disease: Which is the Best Marker, Type III Procollagen, Type IV Collagen, Laminin, Tissue Inhibitor of Metalloproteinase, or Prolyl Hydroxylase?”. Alcoholism: Medical and Experimental Analysis. 20 (9): 1512–7. doi:10.1111/j.1530-0277.1996.tb01692.x. PMID 8986196. ^ Yabu, Ok; Kiyosawa, Ok; Mori, H; Matsumoto, A; Yoshizawa, Ok; Tanaka, E; Furuta, S (2009). “Serum Collagen Type IV for the Assessment of Fibrosis and Resistance to Interferon Therapy in Chronic Hepatitis C”. Scandinavian Journal of Gastroenterology. 29 (5): 474–9. doi:10.3109/00365529409096841. PMID 7518613. ^ Okonogi, H; Nishimura, M; Utsunomiya, Y; Hamaguchi, Ok; Tsuchida, H; Miura, Y; Suzuki, S; Kawamura, T; Hosoya, T; Yamada, Ok (2001). “Urinary type IV collagen excretion reflects renal morphological alterations and type IV collagen expression in patients with type 2 diabetes mellitus”. Medical nephrology. 55 (5): 357–64. PMID 11393380. INIST:985198.
Collagen+sort+IV on the US Nationwide Library of Drugs Medical Topic Headings (MeSH)