StatPearls [Internet].
Introduction
Collagen will be additional divided into a number of teams relying on the kind of constructions they type. There are 28 numerous varieties of collagen which were found, however by far, the commonest are varieties I by means of IV, with kind I comprising over 90% of the collagen within the human physique.[1][2][3]
Fundamentals
The method of collagen synthesis happens primarily within the cells of fibroblasts that are specialised cells with the primary operate of synthesizing collagen and stroma. Though several types of collagen might bear totally different post-translational modifications, the fundamental define for collagen synthesis is listed under. Collagen synthesis happens each intracellularly and extracellularly.
Problems with Concern
Ehlers-Danlos syndrome which can also be an inherited collagen dysfunction with a minimum of 6 totally different subtypes with totally different mutations of various collagen varieties. Lastly, Vitamin C deficiency is a dietary deficiency which ends up in altered hydroxylase enzyme operate which requires Vitamin C as a cofactor. Osteogenesis imperfecta which is an autosomal dominant dysfunction of kind 1 collagen, which may current with a spectrum of findings from delicate to deadly.
Mobile
Collagen Fibril Meeting
Perform
Collagen is essentially the most considerable protein within the human physique. Due to this fact, it may be divided into many sorts. The commonest varieties of collagen are varieties I by means of V every serving totally different features.