†Steadman Philippon Analysis Institute, Vail, Colorado, USA.
Summary
Subsequently, the needs of this systematic overview had been to (1) summarize vitamin C therapy protocols; (2) report on the efficacy of vitamin C in accelerating therapeutic after bone, tendon, and ligament accidents in vivo and in vitro; and (3) report on the efficacy of vitamin C as an antioxidant defending in opposition to fibrosis and selling collagen synthesis. Though laboratory research have reported that vitamin C is crucial for the formation of collagen fibers and cell differentiation, there’s controversy surrounding the efficacy of vitamin C as a complement for scientific therapy. It was hypothesized that vitamin C supplementation would end in decreased oxidative stress and accelerated tissue therapeutic compared with management teams.
Strategies
Outcomes
There have been 7 research that evaluated the results of vitamin C supplementation in animal fashions: 4 after bone fractures (nonoperative therapy), 2 after tendon ruptures (nonoperative and surgical therapy), and 1 after anterior cruciate ligament (ACL) reconstruction (ACLR) (Desk 1). There have been 3 research that evaluated the results of vitamin C supplementation in human fashions: 1 after ACLR and a pair of after bone fractures (nonoperative and surgical therapy). Two of the scientific research had been degree 1 proof, whereas 1 research was degree 2 proof.
Dialogue
Though excessive concentrations of ROS might be deleterious to tissue therapeutic, low concentrations of ROS have been demonstrated to advertise angiogenesis and mesenchymal stem cell proliferation.3 Subsequently, it has been hypothesized that overscavenging of ROS by vitamin C might impair therapeutic in musculoskeletal harm settings.19 Sandukji et al32 reported elevated biomarkers of bone with 60 mg/d of vitamin C, which gives scientific proof for using low doses of vitamin C as a postinjury complement. Nonetheless, there are at present no definitive therapy protocols for the administration of vitamin C. Additional scientific research analyzing a broader vary of oral doses, the efficacy of vitamin C administration by way of parental routes, and the synergistic actions of mixed antioxidant administration are inspired. A number of fundamental science and scientific research investigating tumor growth have reported that the overexpression of antioxidant enzymes and excessive doses of vitamin C (ie, ≥1000 mg/d) might impair wound therapeutic and angiogenesis.29,30,36,40
Conclusion
No antagonistic results had been reported with vitamin C supplementation in both animal fashions or human members; thus, oral vitamin C seems to be a protected complement however lacks scientific proof in contrast with controls. Preclinical research demonstrated that vitamin C has the potential to speed up bone therapeutic after fractures, improve kind I collagen synthesis, and cut back oxidative stress parameters. Due to the restricted variety of human research, additional scientific investigations are wanted earlier than the implementation of vitamin C as a postinjury complement.