Blood Teams and Pink Cell Antigens [Internet].
At a look
Background info
Fundamental biochemistry – “d protein in blood”
Medical significance of Rh antibodies
The Rh antigens are extremely immunogenic, and many of the Rh antibodies needs to be
thought of as potential causes of hemolytic transfusion reactions and HDN.
Whereas most blood sorts are decided by pink cell antigens that differ by one or
two amino acids, the Rh blood group incorporates the D antigen which differs from the
C/c and E/e antigens by 35 amino acids. This massive distinction in amino acids is the
cause why the Rh antigens are potent at stimulating an immune response (4).
Nearly all of antibodies shaped towards the Rh antigens are of the IgG sort. They
are able to inflicting vital HTR and HDN. Rh antibodies hardly ever, if ever, bind
complement, and subsequently RBC destruction is mediated virtually solely through
macrophages within the spleen (extravascular hemolysis).
There are a couple of examples of Rh alloantibodies which are naturally occurring and are of
the IgM sort, however they’re within the minority.
Molecular info
“d protein in blood”