Duke College has patented a secure, concentrated resolution of l-ascorbic acid that delivers increased doses of vitamin C into pores and skin than will be achieved by food plan. New research present that topical vitamin (L-ascorbic acid) is a wonderful antioxidant for UVA and UVB (290 to 320 nm) safety, making it a helpful adjunct to (however not substitute for) sunscreens.1
Vitamin C (L-Ascorbic Acid)
Vitamin C is among the physique’s major protectants from reactive oxygen harm, however it’s depleted throughout ultraviolet damage. Vitamin C serves as the key aqueous part antioxidant in pores and skin. It not solely neutralizes reactive oxygen species damaging to the pores and skin but additionally actively recycles vitamin E, which serves to guard lipids and cell membranes from these oxidative insults. Human beings can not synthesize vitamin C; they have to ingest it, and physique management mechanisms restrict absorption and subsequent supply to tissues. Pores and skin contains about 8% of physique tissues and will get roughly the identical quantity of oral vitamin C. Half-life after ingestion is 12 to twenty days.
Topical L-Ascorbic Acid
As a result of physique management mechanisms restrict the quantity of ingested vitamin C out there to pores and skin, making use of secure L-ascorbic acid topically yields increased concentrations that present further safety. And in contrast to most sunscreens, as soon as vitamin C will get into pores and skin, it can’t be rubbed or washed off or run off with perspiration. The safety appears to final unchanged for days. Topical vitamin C additionally prevents ultraviolet immunosuppression, a response that has been implicated in each melanoma and nonmelanoma pores and skin cancers.
Photoaging
Photoaging adjustments in regular pores and skin have been produced by repeated exposures of modest quantities of UVA mild. Research present that long-wave UVA (340 to 400 nm) alone may cause these adjustments. 3–5 In pores and skin fibroblast tradition, UVA rays, however not UVB, generate a household of matrix metalloproteinases, enzymes that destroy connective tissue. Reactive oxygen species, significantly the singlet oxygen produced by UVA publicity, set off these adjustments, with a mechanism of motion not too long ago recognized.6 Comparable adjustments have been generated experimentally in vivo in human pores and skin. Photoaging appears to be the top results of repeated destruction of connective tissue and ensuing scarring.
Photocarcinogenesis
Solar safety issue (SPF) rankings generate false safety as a result of they measure solely erythema, largely generated by UVB. Customers ought to consider SPF not as solar safety issue, however as sunburn safety issue. UVA safety shouldn’t be mirrored by an SPF quantity. The truth is, no present measure of UVA safety exists.
Photoprotection – “does vitamin c absorb into skin”
The added ranges of L-ascorbic acid achieved by topical utility present photoprotection to pores and skin. Photodamage, which is measured histologically as sunburn cells, will be lessened by L-ascorbic acid (whether or not produced by UVB or UVA), with safety towards UVA harm showing particularly good.8 As a result of L-ascorbic acid doesn’t soak up UVB or UVA mild, its mechanism of motion is totally different from that of sunscreens. L-ascorbic acid appears to guard by neutralizing reactive oxygen species generated by ultraviolet mild. Topical ascorbic acid may even be used to deal with sunburn, presumably by neutralizing irritation. Outcomes so far point out that topical vitamin C is a helpful adjunct to sunscreens.
Ultraviolet Immunosuppression
Immunosuppression by ultraviolet mild for each contact and delayed-type hypersensitivity happens in one in all three people. Nonetheless, virtually everybody with melanoma or nonmelanoma pores and skin most cancers has this response. In animals, ultraviolet immunosuppression is related to extra aggressive metastatic habits. Sadly, sunscreens do not defend very nicely towards ultraviolet immunosuppression. In distinction, topical L-ascorbic acid prevents ultraviolet immunosuppression.9
Collagen Synthesis
Vitamin C is the one antioxidant that has been confirmed to extend collagen synthesis. In human pores and skin fibroblasts in tradition, L-ascorbic acid stimulates collagen synthesis with out affecting different protein synthesis. L-ascorbic acid is thought to be crucial for prolyl hydroxylase, an enzyme important for producing a secure collagen molecule. As well as, L-ascorbic acid is critical for lysyl hydroxylase, an enzyme crucial for cross-linking one collagen molecule to a different collagen molecule, which is required for tissue power. Lastly, L-ascorbic acid indicators collagen genes to synthesize collagen, a response that’s essential in wound therapeutic.
“does vitamin c absorb into skin”