Generic Identify: levomefolate calcium
Dosage Kind: pill, coated
Medically reviewed by Medication.com. Final up to date on Jul 22, 2020.
Disclaimer: This drug has not been discovered by FDA to be secure and efficient, and this labeling has not been permitted by FDA. For additional details about unapproved medication, click on right here.
L-Methylfolate Calcium Description
L-Methylfolate Calcium 7.5 mg is an orally administered prescription dietary complement particularly formulated for the dietary administration of sufferers with distinctive dietary wants requiring elevated folate ranges.
L-Methylfolate Calcium 7.5 mg needs to be administered beneath the supervision of a licensed medical practitioner.
Every coated, spherical, blue pill comprises the next dietary ingredient:
Different elements: Croscarmellose sodium, dicalcium phosphate, magnesium stearate, microcrystalline cellulose, silicon dioxide, stearic acid, and movie coat (FD&C Blue #2, polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide).
FOLATE REGULATION
The time period “folate” are B nutritional vitamins that embrace folic acid and any types of lively pteroylglutamates whatever the discount state of the molecule. Folates, or vitamin B9, are primarily hydrolyzed within the intestinal jejunum and the liver to the lively circulating type of folate, l-methylfolate, with an intermediate secure kind, 5,10-methylenetetrahydrofolate.
People with genetic polymorphisms for the genes coding methylenetetrahydrofolate reductase (MTHFR) might not be able to using or metabolizing folic acid adequately for the vitamin B12 dependent methylation cycle.
Folic acid, together with diminished forms1 resembling folinic acid, might obscure pernicious anemia above 0.1 mg doses, and have to be administered beneath the supervision of a licensed medical practitioner.
The 1971, 1972, 1973, 1980, 1984, 2000, and 2010 Federal Register Notices addressed this concern whereas establishing that elevated folate was correct remedy in megaloblastic anemias – particularly the place homocysteine ranges had been elevated or danger of neural tube defects (NTDs) was at problem. The Federal Register Discover of August 2, 1973 (38 FR 20750) particularly states that:
Folic acid – together with diminished varieties, could also be added to medical meals as outlined in part 5(b)(3) of the Orphan Drug Act (21 USC 360ee(b)(3)), or to meals (21 CFR 172.345).
Indications and Utilization for L-Methylfolate Calcium
L-Methylfolate Calcium 7.5 mg is indicated for the distinct dietary necessities of sufferers in want of dietary supplementation as decided by a licensed medical practitioner.
L-Methylfolate Calcium 7.5 mg needs to be administered beneath the supervision of a licensed medical practitioner.
Contraindications
This product is contraindicated in sufferers with a identified hypersensitivity to any of the elements.
Warnings
Warning is advisable in sufferers with a historical past of bipolar sickness.
Precautions – “l methylfolate calcium tablets 1mg”
Common
Folate, when administered as a single agent in doses about 0.1 mg every day, might obscure the detection of vitamin B12 deficiency (particularly, the administration of folic acid might reverse the hematological manifestations of B12 deficiency, together with pernicious anemia, whereas not addressing the neurological manifestations).
Folate remedy alone is insufficient for remedy of a vitamin B12 deficiency.
A serious depressive episode could be the preliminary presentation of bipolar dysfunction. It’s usually believed, (though not established in managed trials) that treating such an episode with an antidepressant alone might enhance the probability of a precipitation of a combined/manic episode in sufferers in danger for bipolar dysfunction.
L-Methylfolate Calcium 7.5 mg is just not an antidepressant; nonetheless, folate has been proven to reinforce antidepressant results of identified antidepressants. Warning is advisable in sufferers with a historical past of bipolar sickness.
Sufferers with depressive signs needs to be adequately screened to find out if they’re in danger for bipolar dysfunction since temper elevation on this inhabitants is feasible.
PATIENT INFORMATION
L-Methylfolate Calcium 7.5 mg is a prescription dietary complement for use solely beneath licensed medical supervision.
DRUG INTERACTIONS
Medication which can work together with folate embrace:
PREGNANCY and NURSING MOTHERS
L-Methylfolate Calcium 7.5 mg is just not meant to be used as a prenatal/postnatal multivitamin for lactating and non-lactating moms. This product comprises a B vitamin in diminished kind. Speak along with your medical practitioner earlier than utilizing if pregnant or lactating.
Antagonistic Reactions
Allergic sensitization has been reported following each oral and parental administration of folic acid, and should probably happen with different types of folate.
L-Methylfolate Calcium Dosage and Administration
The same old grownup dose is 7.5 to fifteen mg every day with or with out meals or as directed by a licensed medical practitioner.