Store Reg’Activ Merchandise – (*3*) 3 Probiotics
The blue columns symbolize the pre-ME-3 values The orange columns symbolize the improved values after taking ME-3
Research #1:
Title: An antioxidant probiotic reduces postprandial lipemia and oxidative stress. Journal: Central European Journal of Biology. 2011;Vol. 6(1): pp. 32-40.
Authors: Tiiu Kullisaar, Jelena Shepetova, Kersti Zilmer, Epp Songisepp, Aune Rehema, Marika Mikelsaar, Mihkel Zilmer
Topics: 100 clinically wholesome volunteers (75 females, 25 males, age 40-65 years) had been recruited right into a double-blind placebo-controlled randomized research. For numerous causes, 25 individuals within the management group and a pair of within the handled group dropped out. Therefore, the outcomes are based mostly on 48 handled topics and 25 controls.
Research Design: This research utilized kefir with ME-3 added because the take a look at agent and kefir with none probiotic because the management agent. Each kefir options had been an identical nutrient composition, coloration, style, and caloric worth. Volunteers all consumed an an identical customary meal.
Testing: After a 2-week introductory interval, baseline blood and urine samples had been obtained 2.5 hours after ingestion of the usual meal. Then volunteers additionally ingested 200 ml of kefir with ME-3 or management kefir every day for 2 weeks and had been then re-tested.
Outcomes: Volunteers ingesting kefir containing ME-3 exhibited the next: a) -16% in oxidized LDL-cholesterol (reduces heart problems dangers) b) -20% in 8-isoprostanes (discount in free radical harm) c) 10% enhance in HDL-cholesterol (not proven on graph) d) 18% enhance in paraoxonase enzyme exercise (PON1) which regulates
detoxing of pesticides and gives antioxidant exercise (not on graph) e) 10% decline in triglycerides (not proven on graph)
Research #2:
Title: Antioxidative probiotic fermented goats’ milk decreases oxidative stress-mediated atherogenicity in human topics
Journal: British Journal of Vitamin. 2003; Vol. 90; pp.449-456. Authors: Tiiu Kullisaar, Epp Songisepp, Marika Mikelsaar, Kersti Zilmer,
Tiiu Vihalemm, and Mihkel Zilmer Topics: Twenty-one wholesome topics (aged 35-65) divided into 2 teams.
Research Design: throughout the 3-week research, 16 individuals consumed 150 grams of goats’ milk fermented with Lactobacillus fermentum ME-3 (take a look at group) whereas 5 individuals ingested 150 g contemporary goats’ milk with out probiotics (management group).
Testing: Blood and urine samples had been initially examined after which once more on the finish of the 3-week trial. Blood was analyzed for complete antioxidant exercise (TAA), complete antioxidant standing (TAS), ratio of oxidized to lowered glutathione, oxidized LDL-cholesterol and 8- isoprostanes (measure of free radical harm to unsaturated fatty acids). Additionally, fecal samples had been collected at the start (day 0) and once more on the finish of the trial (day 21).
Outcomes: Survivability & Gastrointestinal Persistence: Preliminary testing reported that Lactobacillus fermentum was current within the intestinal tract of solely 4 of the 16 take a look at topics. On the finish of the trial, fecal samples revealed that the GI tract of all 16 take a look at topics had been colonized with ME-3. Moreover, testing additionally revealed that ingesting goats’ milk fermented with Lactobacillus fermentum ME-3 resulted in a doubling of stay ME-3 micro organism within the intestinal tract.
These outcomes present two vital items of information:
a) When taken orally, ME-3 survives transit by abdomen, which suggests it doesn’t get killed when uncovered to robust abdomen acids.
b) When orally ingested ME-3 arrives within the intestinal tract, the micro organism are capable of adhere to the mucosal lining and develop/multiply as evidenced by doubling the focus of stay ME-3 micro organism after 21 days.
Discount of Cardiovascular Dangers: Free radical harm to lipoproteins (oxidized LDL-cholesterol) can in the end harm cells that line the arteries, leading to plaque build-up and atherosclerosis, which is among the major causes of heart problems. ME-3’s antioxidant exercise resulted in a considerable lower in oxidized LDL- ldl cholesterol.
Elevated Antioxidant Safety:
a) The ME-3 take a look at topics exhibited a considerable discount in urinary ranges of 8- isoprostanes (8-EPI) which is acknowledged as one of the crucial dependable methods of measuring oxidative stress.
b) Probably the most vital findings was that oral ingestion of ME-3 resulted in a considerable enchancment within the systemic ratio of lowered (lively) glutathione to oxidized (inactive) glutathione, which signifies a big enchancment in antioxidant safety all through the complete physique.
c) Vital enhance in Complete Antioxidant Exercise (TAA), which additionally signifies an enchancment in each mobile and entire physique antioxidant exercise.
Research #3:
Title: Probiotics, Oxidative Stress, Irritation and Ailments
Publication: 4th Central European Congress on Meals. Could 15-17, Caveat, Croatia.
Authors: Tiiu Kullisaar, Marika Mikelsaar, Sirje Kaur, Epp Songisepp, Kersti Zilmer, Pirje Jutt, Aet Lukmann, Jaak Maaroos, Jaak Kals, and Mihkel Zilmer
Half 1: Atopic Dermatitis: 11 sufferers with atopic dermatitis, ages 20-42 years outdated, randomized into 2 teams. Throughout the 3-month trial, 5 sufferers consumed goats’ milk with ME-3 whereas 6 individuals acted as placebo controls.
Outcomes: Sufferers with atopic dermatitis typically have abnormalities of their glutathione-system together with elevated oxidative stress, irritation and sometimes impaired pores and skin membrane barrier perform. People receiving ME-3 skilled vital enhancements in pores and skin situation, blood markers and in self-assessment score scores.
Half 2: Mind Stroke: 21 sufferers (ages 71-89) who had skilled a mind stroke someday between 8 to 22 days earlier had been randomly divided into 2 teams. Topics consumed both 3 capsules of ME-3 twice every day or 3 placebo capsules twice every day for time that ranged from 10 days to 3 weeks. Sufferers had been evaluated on the Practical Independence Measure stock (FIM) and on the Scandinavian Stroke Scale (SSS).
Outcomes: Stroke sufferers consuming ME-3 exhibited vital enhancements in each the Scandinavian Stroke Scale and the Practical Independence Measure stock. Stroke sufferers additionally skilled spectacular enhancements within the following blood markers: oxidized LDL-cholesterol, glutathione ranges & ratio of lowered to oxidized glutathione, complete antioxidant capability, paraoxonase enzyme exercise in addition to reductions in markers of irritation and free radical harm.
Half 3: Assay of Blood & Urine Markers: 15 wholesome volunteers, ages (40-65). After a 2-week introductory interval, the volunteers had been randomized right into a double-blind, placebo-controlled, crossover trial. People ingested kefir with ME-3 or placebo kefir for 2 weeks. After a 3-week wash-out interval, new blood & urine samples had been taken after which topics crossed over to take the alternate regime for an extra 2 weeks.
Outcomes: Volunteers taking ME-3 skilled enhancements in all blood and urine markers evaluated in comparison with controls.
Doses of Lactobacillus fermentum ME-3 Used within the Human Medical Trials
Capsules: In many of the research the place the take a look at topics had been taking capsules containing Lactobacillus fermentum ME-3, the dose was one billion micro organism per day. Within the mind stroke research, the dose was 6 billion per day.
Kefir: The probiotic doses in kefir are considerably larger, offering roughly 20-30 billion micro organism per day.
NOTE: Although the every day dose of ME-3 is way larger within the kefir supply technique in comparison with the dose of ME-3 in capsules, it’s fascinating to notice that the magnitude of the useful adjustments (oxidized LDL-cholesterol, PON enzyme exercise and complete antioxidant standing) are fairly related within the kefir trials in comparison with the capsule trials. This means giant doses (20- 30 billion) don’t present extra profit past reasonable doses containing a number of billion micro organism. The Reg’Activ formulation comprise from 4 to six billion cfu of ME-3 per day.
Store Reg’Activ Merchandise
Working as a glutathione-activating agent by way of three totally different mechanisms, Reg’Activ is about to affect the way forward for preventative and restorative well being on a mobile stage.