“Athlete — a person who is proficient in sports and other forms of physical exercise”
Athletes are available in all shapes, sizes, and ranges of competitors.
Regardless should you’re a prime tier physique athlete, world class strongman, or weekend warrior, should you’re placing within the work within the health club or on the sphere, you might be an athlete.
Through the years, Superior Molecular Labs has made it its mission to develop premium-quality dietary supplements to help the wants of athletes.
Nowhere is that this higher showcased than our flagship AML PreWorkout complement.
Formulated utilizing elements backed by exhausting science, AML PreWorkout was a revelation to the pre exercise panorama when it debuted at a time that was dominated by pixie-dusted, prop blends.
Since its inception, AML PreWorkout has been the pre-training complement of alternative for athletes of all walks.
However, as we mentioned, athletes are available in all sizes and styles, and there was a need for extra.
Out of this thirst for an edgier, harder-hitting pre exercise arose AML PREWORKOUT X-Treme!
What’s AML PreWorkout X-Treme?
AML PreWorkout X-Treme is probably the most superior scientifically-based pre exercise complement ever developed.
As with all Superior Molecular Labs merchandise, AML PreWorkout X-Treme relies on the most recent cutting-edge efficiency diet, analysis, elements and portions.
AML PreWorkout X-Treme is designed to help elevated power, psychological alertness, muscular endurance, energy, and lean physique mass.
It’s for the intense athlete and health fanatic, properly versed in exhausting coaching, correct diet, and what makes a high quality pre exercise.
Let’s take a deeper look into what makes AML PreWorkout X-Treme a pre exercise in contrast to some other.
What’s in AML PreWorkout X-Treme
Citrulline Malate 2:1
AML PreWorkout provides 8 grams of Citrulline Malate, a confirmed ergogenic support that helps blood move and athletic efficiency.
AML Pre X-Treme ups the ante boosting Citrulline Malate to a heaping 10,000mg per serving!
At a 2:1 ratio of citrulline to malic acid (malate), meaning you’re getting over 6,000mg of pure L-Citrulline per serving!
Why is that this necessary?
L-citrulline is an amino acid that has been discovered to be a extra bioavailable and efficient nutrient for growing plasma ranges of Arginine (the “fuel” of nitric oxide manufacturing within the physique), in comparison with L-Arginine supplementation.[1,2]
Not solely is citrulline simpler than L-arginine, it’s additionally simpler on the GI system than l-arginine, too.[2]
Human research utilizing citrulline malate be aware that it might assist improve the variety of repetitions carried out whereas additionally decreasing a person’s charge of perceived exertion (RPE) versus.[3,4,5]
Analysis additionally signifies that citrulline malate supplementation could assist cut back muscle soreness as much as 40% within the hours following coaching.[5]
Citrulline additionally performs an necessary function in ammonia buffering, which in flip helps cut back lactic acid accumulation as properly and increase train efficiency.
Creatine Monohydrate
Within the annals of sports activities diet, there has but to be an ingredient as rigorously examined or persistently proven to be useful than creatine monohydrate.
Fairly merely, it’s the king of sports activities diet dietary supplements.
The issue with creatine within the overwhelming majority of pre exercises is that it’s woefully underdosed.
That’s not the case with AML PreWorkout X-Treme.
Like its predecessor, AML PreWorkout X-Treme provides the total 5,000mg dose of creatine monohydrate in each serving.
A number of research, critiques, and place stands have famous that creatine supplementation is efficient for enhancing power manufacturing, energy and energy output in addition to supporting lean mass positive aspects.[6,7,8]
Typical protocols for creatine supplementation advocate consuming between 3-5 grams per day on a regular basis with a purpose to attain saturation and derive the advantages of creatine.
Nonetheless, a not too long ago printed examine even discovered that even when creatine is simply supplemented on coaching days, people skilled larger positive aspects in energy and endurance in comparison with placebo.[8]
Beta Alanine
Beta alanine is the ingredient greater than some other that’s synonymous with endurance.
A nonessential amino acid, beta alanine binds to L-Histidine (one other amino acid) to kind the highly effective intracellular buffer, carnosine.
When muscle tissue repeatedly contract, hydrogen ions (H+) start to build up, and as these ions construct up, the muscle pH turns into extra acidic, which ultimately prevents the muscle from persevering with to contract.
Beta alanine is the rate-limiting precursor to carnosine synthesis.[9]
Supplementation with beta alanine will increase carnosine concentrations in skeletal muscle tissue, thereby enhancing a muscle’s capability to buffer H+ ions and delay the onset of fatigue. This helps athletes full extra repetitions and extra whole work earlier than succumbing to fatigue.
AML PreWorkout X-Treme incorporates 3,200mg beta alanine per serving, in comparison with the 2000mg dose contained in AML PreWorkout.
Betaine Anhydrous
Betaine (trimethylglycine) is a pure osmolyte present in a lot of meals widespread to the eating regimen, together with complete grains, shellfish, spinach, and sugar beets.[10]
It performs a key function in a number of features of human well being, together with the methylation of homocysteine.
In case you weren’t conscious, analysis signifies that top ranges of homocysteine could be a danger issue for coronary heart illness.[11]
preserve cell quantity and fluid stability throughout annoying conditions similar to dehydration.
Extra research have famous that diets excessive in betaine might also lower the danger for sure ailments.[10]
As an osmolyte, betaine additionally helps preserve cell quantity and fluid stability, which can assist guard towards dehydration throughout annoying occasions similar to intense train.
Betaine additionally will increase intracellular water[12], which inspires cell volumization and mobile swelling. This promotes muscle development by means of stimulating muscle protein synthesis.
Lastly, a rising physique of literature finds that betaine supplementation could considerably improve anaerobic energy, muscle protein synthesis, and physique composition.[12,13,14,15,16]
L-Tyrosine
Motivation might be elusive at instances, particularly on these days when life will get hectic and/or sleep is briefly provide.
That’s one of many many advantages of pre exercises dietary supplements — they’ll present the “liquid motivation” wanted to get within the health club and crush it, even while you’re not feeling it.
L-Tyrosine is an amino acid that helps biosynthesis of the “motivation and reward” molecule, dopamine, in addition to a number of different extremely necessary neurotransmitters together with epinephrine (adrenaline), and norepinephrine (noradrenaline).
Supplementing with L-tyrosine provides the physique with extra “raw material” to synthesize these extremely necessary neurotransmitters throughout annoying conditions, similar to a excessive quantity leg exercise.
Dopamine isn’t nearly reward and motivation although, it additionally performs an necessary function in temper, reminiscence, and motor management.
Deficiencies within the neurotransmitter can impression motivation, efficiency, temper, and cognition.
Stress (similar to intense train) may also result in reductions of dopamine shops within the mind, resulting in elevated fatigue and diminished athletic efficiency.[17]
AML PreWorkout X-Treme incorporates 2,000 mg of L-Tyrosine — the identical dose proven in human analysis trials to spice up psychological and bodily efficiency in addition to support reminiscence.[17,18,19]
Beet Root Extract
To additional help blood move and complement the actions of citrulline malate, AML PreWorkout X-Treme incorporates a formidable duo of plant-based extracts in beet root extract and grape pores and skin extract.
These botanical extracts are wealthy in antioxidant compounds which were proven to help NO manufacturing and blood move for elevated athletic efficiency.
Peak ATP
ATP is the mobile forex of power manufacturing. The extra quickly muscle fibers can regenerate ATP shops, the longer they may be capable of preserve a excessive stage of efficiency and resist fatigue.
This is without doubt one of the most important causes athletes complement with creatine monohydrate — it will increase a muscle’s skill to quickly regenerate ATP.
Through the years, a lot of exogenous ATP dietary supplements have been explored, however by and huge, they’ve failed (no less than in people anyway) attributable to an absence of bioavailability (even when utilizing doses as excessive as 5,000 mg).[20,21,22]
Peak ATP® is a clinically-researched, patented type of adenosine 5’-triphosphate (ATP) disodium that’s an identical in construction to human ATP.
Analysis has proven that supplementation with Peak ATP could enhance athletic efficiency and physique composition by growing blood move, muscular excitability, and restoration.
Research be aware that Peak ATP® can present profit after only a single dose for growing the ratio of muscle activation and energy output throughout high-intensity train.
It could additionally assist cut back protein breakdown and forestall efficiency drop-off as a person will get deeper into their exercise.[23,24,25,26]
The landmark Peak ATP examine from 2013 carried out in people famous[23,63]:
Moreover, Peak ATP supplementation has been documented to cut back systolic blood strain after cardio train in comparison with placebo.[27]
Researchers additionally famous that ATP supplementation could assist to potentiate the parasympathetic restoration after train, thereby encouraging quicker restoration of HRV following train.[27]
AML PreWorkout X-Treme provides the research-backed 450mg dose of Peak ATP in each serving.
Caffeine Anhydrous
In the event you’re in search of an X-Treme preworkout complement, then chances are high very excessive you’re well-acquainted with caffeine…maybe even a bit too well-acquainted.
Caffeine is the spine of all pre exercise dietary supplements.
It will increase psychological power, focus, and motivation whereas additionally enhancing athletic efficiency and resistance to fatigue.
Maybe, extra importantly, caffeine has been extensively researched and never solely confirmed to be efficient for enhancing efficiency, however protected (when utilized in moderation).[28]
The identical CANNOT be mentioned of different stimulants generally utilized in pre exercise dietary supplements, similar to higenamine, hordenine, or PEA — none of that are included in AML PreWorkout or AML PreWorkout X-Treme.
Caffeine’s most important mechanism of motion (and first avenue of profit) is by way of antagonism of adenosine, a neurotransmitter within the mind that induces emotions of lethargy and tiredness. By stopping adenosine from binding to its companion receptor, caffeine promotes elevated emotions of wakefulness, alertness, and reactivity.
Caffeine additionally potentiates the discharge of dopamine within the mind in addition to upregulates dopamine receptor availability and affinity.[29,30]
That is a part of the explanation why taking a pre exercise that features caffeine (or having a cup of espresso) appears to spice up temper — elevated dopamine!
AML PreWorkout X-Treme incorporates the identical 400mg dose of caffeine discovered within the authentic AML PreWorkout.
This dose is consistent with analysis noting enhancements in energy and energy output in athletes.
TeaCrine 40%
Caffeine is famend for its skill to impart a speedy infusion of power, motivation, and focus. Nonetheless, the half-life of caffeine is simply round 5.5 hours.
TeaCrine is a chemical cousin of caffeine that enhances the rapid burst provided by the well-known stimulant by offering easy, sustained power.
TeaCrine is that patented type of theacrine — a naturally occurring compound present in a lot of vegetation, specifically kucha tea Coffea robusta.
TeaCrine works much like caffeine, in that it impacts each adenosine and dopamine receptors, however the method through which it does so is barely completely different than caffeine (which is why the 2 have a synergistic impact when taken collectively).[31]
This creates a “best of both worlds” strategy to power enhancement with caffeine offering the acute, highly effective improve in power and application and TeaCrine supplying a sustained, “slow burning” power.
Analysis has proven that the mix of caffeine + TeaCrine favorably impacts endurance and the mix offers larger advantages on cognitive perform than both complement taken independently.[32]
Maybe better of all TeaCrine doesn’t include habituation (tolerance construct up), which implies you get the identical improve in power, with out having to repeatedly improve the dose used (the identical of which might’t be mentioned for different pre exercise stimulants).
AdvantraZ (P-Synephrine)
Advantra Z® is a patented extract of Citrus Aurantium (a.okay.a. Bitter Orange), a fruit wealthy in a lot of alkaloids identified to help weight reduction and train efficiency.
Whereas citrus aurantium could include a lot of alkaloids, the one we’re primarily keen on is p-synephrine.
p-synephrine is structurally much like ephedrine however considerably weaker (which is an effective factor). It’s been famous to extend power expenditure, put up train oxygen uptake, and fats oxidation, which result in enhancements in repetition efficiency and quantity load throughout coaching.
Another analysis signifies there’s an additive impact when combining p-synephrine with caffeine.[33,34]
Particularly, combining caffeine with 100mg p-synephrine (the identical dose included in AML PreWorkout X-Treme) was famous to assist athletes obtain quicker, extra highly effective repetitions all with no extra perceived exertion or lactate accumulation![33]
Whereas p-synephrine is structurally much like ephedrine, it’s not the identical compound, nor does it behave the identical method m-synephrine does.
Each ephedrine and m-synephrine are banned substances in dietary dietary supplements.
Moreover, p-synephrine has nearly no binding affinity for α-1 and α-2 in addition to β-1 and β-2 adrenoreceptors.[35]
p-Synephrine does, nonetheless, agonize the β-3 adrenoreceptor, which ends up in elevated metabolic charge and lipolysis, and it might additionally assist cut back meals consumption.
AML PreWorkout incorporates the research-backed dose of 100mg of p-synephrine (as AdvantraZ) which was famous to enhance efficiency as demonstrated by elevated whole quantity of repetitions, implying athletics who supplemented with p-synephrine exhibited elevated muscle endurance.
AML PreWorkout X-Treme makes use of solely the patented, quality-verified AdvantraZ.
Many different pre exercise dietary supplements available on the market embrace generic citrus aurantium extracts, which generally include between 6-8% p-synephrine.
Nonetheless, a current examine discovered that many dietary supplements using generic citrus aurantium extracts didn’t meet label claims. Solely 22% of the merchandise examined truly contained the quantity of synephrine they claimed.
Researchers additionally detected the presence of artificial amines, together with methylsynephrine and isopropyloctopamine, neither of which results are well-studied in people.[36]
Grape Pores and skin Extract (30% Polyphenols)
As we talked about above, AML PreWorkout X-Treme incorporates a pair of botanical extracts to enrich and improve the vasodilating results of citrulline malate.
We’ve already lined beetroot, and now we shift the main target to grape pores and skin extract.
Grape pores and skin extract is wealthy in a wide range of polyphenols which have been famous to stimulate endothelial nitric oxide synthase (eNOS) and enhance train efficiency.
Analysis signifies that supplementing with polyphenol-rich extracts could considerably improve common energy (5%), whole energy output (5%), and maximal peak energy output (3.7%).[37]
Extra analysis notes that supplementation with grape pores and skin extract can cut back muscle injury after excessive depth energy coaching.[38,39]
AML PreWorkout X-Treme incorporates 100mg grape pores and skin extract (standardized to 30% polyphenols).
Velvet Bean Extract
Above, we mentioned the significance dopamine performs in motivation in addition to train efficiency.
And to help dopamine manufacturing throughout annoying conditions, AML PreWorkout X-Treme contains 2,000mg L-Tyrosine.
However, this may be additional improved by the addition of velvet bean extract, which incorporates L-3,4-dihydroxyphenylalanine (L-DOPA) — the direct precursor to dopamine.
L-Dopa is of course occurring within the physique, and it’s additionally readily present in Velvet Bean (Mucuna pruriens).
Velvet bean has lengthy been utilized in conventional medication as a tonic and aphrodisiac attributable to its broad spectrum of actions.
Moreover, velvet bean has additionally been proven to be neuroprotective and exert analgesic (pain-relieving) and anti inflammatory properties.[40]
Folic Acid
Persevering with on with vitamins that help dopamine synthesis within the physique brings us to Folic Acid.
This extremely bioavailable type of vitamin B9 is required for the manufacturing of cofactor BH4 (tetrahydrobiopterin), thereby supporting the manufacturing of dopamine.
Analysis notes an affiliation between low dopamine ranges (that are linked to melancholy) and low intakes of folic acid.[41]
Supplementing with folic acid helps dopamine manufacturing by offering the physique with essential substrate required to construct the enzyme which is taken into account the “rate-limiting” step within the synthesis of dopamine.[42]
You may also have an interest to know that BH4 is a vital cofactor for the synthesis of nitric oxide.[43]
Basically, folic acid is a vital “support” ingredient usually missed in different pre exercises that performs key roles within the manufacturing of each dopamine and nitric oxide — each of which impression train efficiency.
BioPerine®
BioPerine is the widely known, trade main black pepper extract sometimes included for its skill to enhance nutrient bioavailability. BioPerine is ready to due this because of the presence of its main bioactive, piperine, which inhibits the drug-metabolizing enzyme CYP3A4 in addition to the drug transporter P-glycoprotein.[44]
Inhibition of CYP3A4 might help lengthen the “lifespan” of assorted vitamins, thereby growing their efficacy and period of results.
Piperine additionally has been famous to extend dopamine by way of activation of the TRPV receptor within the mind.[45]
Lastly, piperine additionally capabilities as a light MAO inhibitor.[46]
MAO (monoamine oxidase) is the enzyme that breaks down mood-boosting neurotransmitters within the physique, together with serotonin and dopamine.
Inhibiting MAO could assist dopamine ranges stay elevated longer for larger power, temper, and motivation!
Electrolytes
Rounding out the excellent ingredient profile of AML PreWorkout X-Treme are the electrolytes — magnesium citrate and potassium citrate.
Electrolytes are important for hydration in addition to serving to athletes keep away from cramping and fatigue throughout coaching.
Moreover, potassium and magnesium additionally help cardiovascular well being and athletic efficiency.
Analysis notes that potassium can soften the endothelium and improve nitric oxide manufacturing.[47]
Magnesium additionally causes vasodilation by growing nitric oxide synthase exercise.[48]
AML PreWorkout X-Treme makes use of the citrate types of these important electrolytes as they’ve been proven to be bioavailable and citrate has additionally been famous to enhance train efficiency by buffering lactic acid buildup within the muscle.[49,50]
In whole, AML PreWorkout X-Treme offers 1,000mg of potassium and 100mg of magnesium per serving.
The explanation for these dosages is that analysis signifies that a good portion of the inhabitants doesn’t devour sufficient dietary potassium, and excessive potassium diets have additionally been proven to assist decrease blood strain.[61,62]
Extra magnesium shouldn’t be included as a result of it may well trigger gastric upsetness and unfastened bowels in some people.
What’s Not in AML Pre X-Treme
What’s not included in a pre exercise is simply as necessary as what’s included in it.
Subsequent, we focus on a number of widespread pre exercise elements that you’ll NOT discover in AML Pre Exercise X-Treme.
Glycerol
Glycerol has lengthy been used for its skill to advertise a state of hyperhydration, attributable to its outstanding osmolytic properties.
Endurance athletes most continuously add glycerol (within the type of a 20% glycerol resolution) to their liquids consumed in and round coaching.
Nonetheless, the analysis on glycerol and efficiency is combined.[51,52]
Furthermore, the doses of glycerol utilized in these research far exceed the 1-3 grams of glycerol (within the type of 65% glycerol-containing dietary supplements) you’ll discover in pre exercises.
You see, glycerol is extraordinarily hygroscopic, which means it attracts water. To stop this clumping and caking in dietary dietary supplements, glycerol liquid is dried right into a powder and combined with copious quantities of silicon dioxide.
The FDA has set higher limits on the consumption of silicon dioxide to not exceed 2% of meals whole weight. That is primarily as a result of quantities larger than set limits haven’t been sufficiently studied
It’s additionally value mentioning that animal research point out that consumption of glycerol monostearate (GMS) will increase the publicity to phthalate esters, which might cut back testosterone ranges.[53]
For these causes, AML PreWorkout X-Treme incorporates no glycerol.
It could be useful should you’re coaching exterior in sizzling/humid situations for a number of hours, since glycerol could assist forestall dehydration, however for the athlete coaching within the health club for 60-75 minutes, there’s little profit available.
In the event you do need glycerol, probably the most value efficient possibility is to buy pure glycerol liquid and add it to your pre exercise.
Unproven Stimulants
As we talked about above when discussing caffeine, AML PreWorkout X-Treme does NOT include any unproven/unsafe stimulants similar to Higenamine, Hordenine, or Phenylethylamine (PEA).
We’ve mentioned at size the problems with these compounds in our articles titled:
With out rehashing the whole thing of each articles, primarily, the stimulants lack in depth security/efficiency analysis in wholesome human topics.
Moreover, as mentioned within the “Higenamine Concerns” article, nearly all of dietary supplements utilizing higenamine failed to satisfy label claims. And, there aren’t any research investigating the results of oral higenamine supplementation by itself on athletic efficiency in human beings.
For these causes, AML PreWorkout and AML PreWorkout-Xtreme use solely caffeine and encompass it with a complementary assortment of focus aids and efficiency boosters that culminate within the consummate pre exercise complement!
Taurine
Taurine is an amino acid generally present in power drinks and lots of pre exercise dietary supplements.
It serves many roles within the physique, together with that of an osmolyte and antioxidant.
Whereas this may sound useful within the context of a coaching session, analysis investigating the mix of caffeine + taurine didn’t discover enchancment efficiency, power, or consideration.[54,55,56,57]
Nonetheless, researchers did be aware that the mix of caffeine + taurine did negatively impression emotions of vigor and reduce the stimulating results of caffeine.
Maybe most fascinating, combining caffeine and taurine was famous to extend emotions of fatigue in topics.
Agmatine
Agmatine is a spinoff of the amino acid L-arginine generally included in pre exercise dietary supplements to help nitric oxide manufacturing and improve muscle pumps.
This is because of some animal analysis indicating that agmatine could stimulate eNOS and inhibit arginase — the enzyme that breaks down arginine.[58,59]
Theoretically, agmatine may assist enhance nitric oxide manufacturing and blood move by way of these two mechanisms, however there’s a succinct lack of analysis investigating the NO-boosting potential of agmatine in people.
There’s some analysis that agmatine supplementation could have some neurological and/or endocrine advantages, together with a discount in perceived ache[60], however there’s subsequent to nothing concerning agmatine and its results on athletic efficiency in people.
As such, agmatine shouldn’t be included in AML PreWorkout X-Treme.
Takeaway
Pre exercise dietary supplements, like athletes, are available in all sizes and styles.
Some people need no stims, some need low stims, and others what a pre exercise complement that dwarfs all others.
AML PreWorkout X-Treme was formulated by athletes for athletes utilizing the most recent scientific analysis. The intention was to create a complicated pre exercise complement constructed to resist probably the most rigorous of coaching protocols, serving to athletes push more durable and last more.
In the event you’re in search of a pre exercise to take your efficiency to the intense, attempt AML PreWorkout X-Treme!
References – “pre workout extreme”