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He increasing prevalence of vitamin D deficiency and insufficiency and its association with an increased risk of autoimmune diseases and poor respiratory function, including asthma. These and additional studies have raised interest in the immunomodulatory properties of vitamin D beyond its well-established role in calcium homeostasis and bone health. Vitamin D has been shown to influence the function of cells intrinsic to innate and adaptive immunity.
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Introduction
The global burden has risen with the near tripling in the last half-century of multiple sclerosis (MS) (2, 3), type 1 diabetes (T1D) (4), and other autoimmune diseases.