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Overview
From 2004-2018 the Workplace of Dietary Dietary supplements (ODS) on the Nationwide Institutes of Well being (NIH) led and sponsored a number of efforts to advance scientific understanding of the significance of vitamin D to well being. These efforts included:
ODS additionally sponsored a number of conferences and workshops on vitamin D. On December 2-3, 2014, ODS sponsored a convention titled, “Vitamin D: Moving Toward Evidence-based Decision Making in Primary Care,” in collaboration with federal cosponsors. This convention offered a discussion board to establish and focus on points targeted on evidence-based choice making for vitamin D in main care settings. Additionally, analysis gaps and knowledge wants related to enhancing approaches and lowering uncertainties surrounding vitamin D have been highlighted. A abstract of the convention shows and discussions has been ready and the convention will also be seen in its entirety from hyperlinks discovered on the 2014 Vitamin D convention webpage.
Figuring out a Analysis Hole: The Vitamin D Paradox. On the 2014 ODS convention questions have been raised concerning the efficacy of vitamin D supplementation amongst Black American populations and the potential dangers related to assuming a “normal” vary of serum 25(OH)D ranges with out adequately assessing well being outcomes in varied subpopulations. These questions have been primarily based on findings displaying that though there’s a correlation of serum 25(OH)D ranges with bone mineral density and fracture danger in White and Mexican-American populations, serum 25(OH)D ranges don’t correlate with the identical well being outcomes in another populations, significantly Black Individuals. In that group, bone density measures are excessive regardless of markedly low or poor serum ranges of 25(OH)D.
To handle these and different questions pertaining to this vitamin D paradox, ODS, with the Nationwide Institute on Minority Well being and Well being Disparities, the Nationwide Institute on Getting old, and the Nationwide Institute of Diabetes and Digestive and Kidney Illnesses, co-sponsored an knowledgeable panel assembly on December 1, 2017, titled, “A Systems-Based Approach to Investigating the Vitamin D Paradox in Black American.” The knowledgeable panel assembly was a discussion board to: (1) discover the paradox via varied multidisciplinary lenses (genetics, epigenetics, molecular mechanisms, and habits) to find out the components affecting vitamin D necessities in Black Individuals; (2) establish potential unintended penalties of present scientific practices and public well being polices (e.g., vitamin D supplementation, meals fortification) on minority well being and well being disparities; and, (3) support in figuring out whether or not further enter from the scientific group through a subsequent workshop is required to advance the understanding of the vitamin D paradox and bone well being within the Black American inhabitants. In her weblog, Dr. LaVerne Brown offers an outline of this assembly and introduces the knowledgeable panel assembly report each of that are printed in BMC Proceedings.
Vitamin D Standardization Program (VDSP)
As a part of its Vitamin D Initiative, the NIH Workplace of Dietary Dietary supplements (ODS) established the Vitamin D Standardization Program (VDSP) in 2010 and coordinated its efforts till 2018. VDSP is a global collaborative effort to standardize the laboratory measurement of vitamin D standing. The VDSP aim is to enhance the detection, analysis, and therapy of vitamin D deficiency and insufficiency by selling the standardized laboratory measurement of serum complete 25-hydroxyvitamin D [25(OH)D] by making it correct and comparable over time, location, and laboratory process.
The VDSP invovled the coordinated efforts of ODS; the Nationwide Institute for Requirements and Expertise (NIST); the Facilities for Illness Management and Prevention (CDC); the Vitamin D Exterior High quality Evaluation Scheme (DEQAS); the School of American Pathologists (CAP); the American Affiliation for Medical Chemistry (AACC); the Worldwide Federation of Medical Chemistry and Laboratory Medication (IFCC); the Laboratory for Analytical Chemistry; College of Pharmaceutical Sciences; Ghent College, Ghent, Belgium; plus nationwide surveys and collaborators around the globe. Because the inception of VDSP, ODS enlisted the participation of nationwide well being surveys from Australia, Canada, Germany, Eire, Mexico, South Korea, the UK, and america.
A public assembly to showcase the VDSP’s progress since 2010 was held on the NIST campus on November 14, 2013. See details about the assembly, together with the shows.
ODS’s coordination of the VDSP concluded in 2018, following a gathering held November 28-30, 2017 which assessed program achievements and outlined future stakeholder-driven efforts, together with an analysis of VDSP efficiency standards for 25(OH)D, the promotion of the standardization of 24,25(OH)2D3 and Vitamin D Binding Protein measurements, and the event of a rickets registry.
ODS Vitamin D Reality Sheets – “vitamin d nih”
ODS has vitamin D reality sheets in two variations—Well being Skilled and Shopper. The Shopper model is obtainable in each English and Spanish.
Vitamin D Sources for Researchers
We have collected helpful vitamin D assets from our workplace and different federal authorities workplaces to supply to researchers, together with our Vitamin D Well being Skilled Reality Sheet, NIH convention proceedings, Normal Reference Materials®, evidence-based evaluations, and different publications.
Convention Proceedings