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It has been proposed that dietary supplementation of vitamin E may reduce a woman’s risk of developing breast cancer. A dose-dependent inhibition of cell proliferation was found in estrogen receptor (ER)-positive cells showing a potent suppression of growth at 100 microM vitamin E in MCF-7 (53%) and T47D (75%) cells. No growth inhibition was observed when cells were grown in the absence of estrogen.
Vitamin E altered and decreased the growth inhibition induced by tamoxifen (10 microM) in MCF-7 (33%) and T47D (54%) cells. This provides evidence that vitamin E may inhibit ER-positive cell growth by altering the cellular response to estroge.
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Intervention(s): After enrollment, all women were studied at baseline and received vitamin E for 4 weeks.
They were then randomized from week 4 to week 12 to receive vitamin E in conjunction with conjugated equine estrogen (CEE) (0.625 mg), CEE (0.625 mg) plus medroxyprogesterone acetate (MPA) (2.5 mg), or placebo. Result(s): Vitamin E levels increased to a similar extent in all three groups compared with baseline at weeks 4 and 12. Vitamin E increased serum interleukin-6 levels.
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Design
Prospective, observational study, followed by a randomized, prospective, double-blind study. Setting
Healthy volunteers in an academic medical referral center in Dallas, Texas. However, there were no consistent statistically significant effects on six other inflammatory markers.
Vitamins And Minerals
B vitamins B vitamins play an important role in the creation and activation of estrogen in the body. Results indicated that higher levels of vitamins B-2 and B-6 were associated with a lower risk of breast cancer, which may be due to the impact of these vitamins on estrogen metabolism. The link between these hormones is due to the role that vitamin D plays in estrogen synthesis.
Boron Boron is a trace mineral that has a variety of roles in the body. It’s been researched for its positive benefits on reducing the risk of certain types of cancer. Within the body, DHEA is first converted to androgens and then further converted to estrogens.
One study also found that DHEA may be able to provide similar benefits in the body as estrogen.