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Aside from its established role in blood clotting, several studies now support a critical function of vitamin K in improving bone health. Several observational and interventional studies have examined the relationship between vitamin K and bone metabolism, but findings are conflicting and unclear.
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Conclusions: Epidemiological studies and clinical trials consistently indicate that vitamin K has a positive effect on bone mineral density and decreases fracture risk.
The effects of coumarin-based anticoagulants on bone health are more ambiguous, with retrospective studies suggesting that long-term therapy adversely affects vertebral BMD and fracture risk. Anticoagulants that do not affect vitamin K metabolism are now available and make clinical trials feasible to answer the question of whether coumarins adversely affect bone. The research suggests that at a minimum, clinicians should carefully assess anticoagulated patients for osteoporosis risk, monitor BMD, and refer them to dietitians for dietary and supplement advice on bone health.
Further research is needed to make more efficacious decisions about vitamin K intake, anticoagulant therapy, and bone healt.
Vitamin K And Osteoporosis
Ten touted as a way to strengthen bones, taking vitamin K for osteopenia does not protect postmenopausal women from age-related declines in bone density, a new study shows. But it may help them avoid fractures or cancers.
“It is intriguing and gives us reason for additional research.”. Cheung says the women were either given a vitamin K supplement or a placebo for two years, with 261 continuing for two more years. “But fewer women over the four-year period had fractures, and fewer had cancer.
Metabolism
Is a liposoluble vitamin. The predominant dietary form, phylloquinone or vitamin K1, is found in plants and green vegetables; whereas menaquinone, or vitamin K2, is endogenously synthesized by intestinal bacteria and includes several subtypes that differ in side chain length. This systematic review aims to investigate the impact of vitamin K (plasma levels, dietary intake, and oral supplementation) on bone health with a particular interest in bone remodeling, mineral density and fragility fracture.