Protein Z (PZ or PROZ) is a protein which in people is encoded by the PROZ gene.[2][3]
Protein Z is a member of the coagulation cascade, the group of blood proteins that results in the formation of blood clots. It’s a gla area protein and thus vitamin Okay-dependent, and its performance is due to this fact impaired in warfarin remedy. It’s a glycoprotein.
Contents
Physiology[edit]
Though it’s not enzymatically energetic, it’s structurally associated to a number of serine proteases of the coagulation cascade: components VII, IX, X and protein C. The carboxyglutamate residues (which require vitamin Okay) bind protein Z to phospholipid surfaces.
The primary function of protein Z seems to be the degradation of issue Xa. That is accomplished by protein Z-related protease inhibitor (ZPI), however the response is accelerated 1000-fold by the presence of protein Z. Oddly, ZPI additionally degrades issue XI, however this response doesn’t require the presence of protein Z.
In some research, deficiency states have been related to a propensity to thrombosis. Others, nonetheless, hyperlink it to bleeding tendency; there isn’t a clear rationalization for this, because it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis.
Genetics[edit]
It’s 62 kDa massive and 396 amino acids lengthy. The PROZ gene has been linked to the thirteenth chromosome (13q34).
It has 4 domains: a gla-rich area, two EGF-like domains and a trypsin-like area. It lacks the serine residue that will make it catalytically energetic as a serine protease.
Historical past[edit]
Protein Z was first remoted in cattle blood by Prowse and Esnouf in 1977,[4] and Broze & Miletich decided it in human plasma in 1984.[5]
Construction[edit] – “z protein”
Structural evaluation of protein Z will enable higher understanding of its operate. The Ramachandran plot for protein Z signifies it’s going to kind alpha helices. The ultimate construction, all alpha area, was decided by x-ray diffraction. It consists of chain A and B, that are each helix-loop-helix motifs.[1]
References[edit]
Exterior hyperlinks[edit]
“z protein”