1Poznan College of Life Sciences, ul. Wojska Polskiego 31, 62-624 Poznan , Poland
2Orenburg State Medical College, Sovetskaya St., 6, Orenburg, 460000 Russia
3Orenburg State College, Pobedy Avenue, 13, Orenburg, 460018 Russia
4RUDN College, Miklukho-Maklay St., 10/2, Moscow, 117198 Russia
5Yaroslavl State College, Sovetskaya St., 14, Yaroslavl, 150000 Russia
3Orenburg State College, Pobedy Avenue, 13, Orenburg, 460018 Russia
4RUDN College, Miklukho-Maklay St., 10/2, Moscow, 117198 Russia
5Yaroslavl State College, Sovetskaya St., 14, Yaroslavl, 150000 Russia
6All-Russian Analysis Institute of Medicinal and Fragrant Vegetation (VILAR), Grina St., 7, Moscow, 117216 Russia
1Poznan College of Life Sciences, ul. Wojska Polskiego 31, 62-624 Poznan , Poland
Summary
Introduction
Zinc (Zn) is among the most typical hint components within the human physique and performs a considerable position in progress and improvement, performing as a signaling issue [1]. This steel takes half within the regulation of power inflammatory standing via the discount of inflammatory cytokines. Zinc additionally reduces oxidative stress by collaborating within the synthesis of antioxidant enzymes and acts as a catalyzer of enzymes, participating in lipid, carbohydrate, and protein metabolism. It’s concerned within the synthesis, storage, and launch of insulin, which suggests the vital position of this microelement within the development of type-2 diabetes mellitus, atherosclerosis, and metabolic syndrome (MS) [2–5].
Research of zinc focus within the human physique are scarce, and have proven inconsistent outcomes. Zinc deficiency has been noticed in sufferers in some counties with elevated oxidative stress and technology of inflammatory standing and the lower concentrations of this component happen in sufferers with MS [3], in sufferers with sort 2 diabetes mellitus [6] and with hypertension [7] than in wholesome folks.
Some research confirmed that prime focus of zinc is related to impaired lipid profile and danger of MS [8–10]. Within the final research, improve in erythrocyte zinc focus and excessive zincuria was noticed in sufferers with MS [11]. Obtained outcomes point out that zinc is strongly related to oxidation stress, irritation, and lipid and glucose standing and it may be assumed that zinc standing could also be a predictor of metabolic issues.
Taking collectively, present information displays the necessity for a vital overview of the zinc position in metabolic issues. The proposed assessment summarizes the advances of the final years (2010–2017), offering new insights into the affiliation between zinc standing and irritation, oxidative stress, lipid, and glucose metabolism.
Conclusions and views
Zinc is a necessary hint component that performs a considerable position within the prevention of metabolic syndrome, together with atherogenic dyslipidemia, hyperglycemia, insulinemia, and elevated blood strain via the inhibition of proinflammatory cytokine expression, which suppresses ROS manufacturing, defending in opposition to oxidative stress harm. Zinc takes half in ROS neutralization in addition to in glucose and lipid metabolism. Zinc is thus extremely important within the pathogenesis of metabolic syndrome, which means that zinc supplementation would have a constructive impact in regressing metabolic syndrome.
Additional investigations of the connection between Zn and cytokines, adipokines, antioxidants, and receptors are wanted to clarify the position of zinc in well being and illnesses. Modulation of zinc standing might change into a brand new goal within the prevention and remedy of metabolic issues. It has been proven that Zn transporters play the essential position in zinc homeostasis within the physique [1]. It appears that evidently deeper information about physiological capabilities of Zn transporters and the flexibility to regulate their exercise could also be an essential consider creating new therapies for Zn-related illnesses.
Acknowledgements
Writer contribution – “zinc metabolism”
JO collected literature and drafted the manuscript; AT and AS drafted the manuscript and ready the figures; JS developed the idea and drafted the manuscript; JO, AT, AS, and JS edited and revised the manuscript and authorised the ultimate model of the manuscript.
Compliance with moral requirements
References
“zinc metabolism”