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Omized, double-blind placebo-controlled study of pyridoxine hydrochloride (vitamin B6) for the treatment of nausea and vomiting of pregnancy. Patients were categorized according to the presence of vomiting: severe nausea (score greater than 7) or mild to moderate nausea (score of 7 or less). The severity of nausea (as graded on a visual analogue scale of 1-10 cm) and the number of patients with vomiting over a 72-hour period were used to evaluate response to therapy.
At the completion of 3 days of therapy, only eight of 31 patients in the vitamin B6 group had any vomiting, compared with 15 of 28 patients in the placebo group (P less than .05).
Abstract
Herb based formulations can be effectively used for the treatment nausea and vomiting observed during pregnancy. Aim: To investigate the effect of ginger in nausea and vomiting during pregnancy in comparison with vitamin B6 and placebo.
Materials and Methods: This is a randomized and double-blind clinical trial. The women who had nausea and vomiting and did not take any medications were included in this study. They were given treatment for 4 days and were followed after a week.
The instrument used in this study was a questionnaire, including demographic characteristic and determining severity nausea and vomiting based on the analog visual scale. Data were analyzed with SPSS software and t-test and Kruskal-Wallis test. Results: There was significant difference between groups in severity of nausea and frequency of vomiting (P < 0.001).
Conclusion: Ginger was effective in treating nausea and vomiting in pregnancy, but its use needs further studies to determine the proper dosage and the confirmation about the safety of this drug for a pregnant mother and her fetus.
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Studies suggest that taking vitamin B6 for morning sickness greatly improves nausea, though not vomiting, for many pregnant women. Intake of more than 100 mg a day of vitamin B6 can cause temporary nerve damag.
What Is Morning Sickness And Who’S Affected?
The American Academy of Family Physicians (AAFP) notes that morning sickness, defined as nausea and vomiting during pregnancy, will affect almost 75 percent of all pregnant people. Morning sickness can be one of the earliest signs of pregnancy, beginning around the sixth week. You can blame it on those rising pregnancy hormones.
For many, morning sickness seems to stop around weeks 12 to 14, but for others, it continues for much longer.