Trial 1
Within the first trial, 81 individuals with osteoarthritis have been randomly chosen to obtain placebo tablets or one among three gelatine (collagen hydrolyse) preparations. Contributors within the lively therapy teams have been handled day by day with 10 g of every gelatine product (0.5 g every pill) for 2 months.
All three gelatine preparations have been considerably higher than the placebo in decreasing ache on the finish of the trial interval, however they didn’t trigger any radiological or laboratory modifications.
The most typical side-effect was heaviness within the abdomen.
Trial 2
This trial included 389 folks with osteoarthritis throughout 20 websites within the UK, USA and Germany. Contributors have been randomised to obtain both 10 g of collagen hydrolysate or placebo tablets for twenty-four weeks.
Collagen hydrolysate had no vital impact on decreasing ache and enhancing bodily operate within the complete examine group.
There was a helpful impact in individuals who had extreme signs at the beginning of the examine.
Collagen hydrolysate was comparatively nicely tolerated.
Trial 3
On this trial, 250 folks with osteoarthritis of the knee have been randomised to obtain both 10 g collagen hydrolysate or a placebo day by day for six months.
Those that acquired collagen reported a higher discount in ache.
Probably the most steadily reported side-effects have been:
migraines
complications
gastrointestinal results.
Trial 4
Trial 4 included 29 folks with delicate to reasonable osteoarthritis of the knee. Contributors got both a collagen formulation (Fortigel®) or a placebo for twenty-four weeks.
On the finish of the examine, there have been no reported variations within the following:
ache
stiffness
operate
strolling.
Trial 5
Within the last RCT, 52 individuals with osteoarthritis of the knee got 10 mg bioactive undenatured sort II collagen or glucosamine hydrochloride plus chondroitin as soon as a day for 3 months.