StatPearls [Internet].
Introduction
Collagen will be additional divided into a number of teams relying on the kind of constructions they type. There are 28 varied kinds of collagen which have been found, however by far, the commonest are varieties I by means of IV, with kind I comprising over 90% of the collagen within the human physique.[1][2][3]
Fundamentals
The method of collagen synthesis happens primarily within the cells of fibroblasts that are specialised cells with the primary operate of synthesizing collagen and stroma. Though several types of collagen could bear completely different post-translational modifications, the essential define for collagen synthesis is listed under. Collagen synthesis happens each intracellularly and extracellularly.
Problems with Concern
Ehlers-Danlos syndrome which can be an inherited collagen dysfunction with at the least 6 completely different subtypes with completely different mutations of various collagen varieties. Lastly, Vitamin C deficiency is a dietary deficiency which ends up in altered hydroxylase enzyme operate which requires Vitamin C as a cofactor. Osteogenesis imperfecta which is an autosomal dominant dysfunction of kind 1 collagen, which might current with a spectrum of findings from gentle to deadly.
Mobile
Collagen Fibril Meeting
Function
Collagen is essentially the most plentiful protein within the human physique. Subsequently, it may be divided into many varieties. The most typical kinds of collagen are varieties I by means of V every serving completely different features.