StatPearls [Internet].
Introduction
Collagen will be additional divided into a number of teams relying on the kind of buildings they type. There are 28 varied varieties of collagen which were found, however by far, the commonest are sorts I by IV, with sort I comprising over 90% of the collagen within the human physique.[1][2][3]
Fundamentals
The method of collagen synthesis happens primarily within the cells of fibroblasts that are specialised cells with the primary perform of synthesizing collagen and stroma. Though various kinds of collagen could bear completely different post-translational modifications, the fundamental define for collagen synthesis is listed under. Collagen synthesis happens each intracellularly and extracellularly.
Problems with Concern
Ehlers-Danlos syndrome which can be an inherited collagen dysfunction with a minimum of 6 completely different subtypes with completely different mutations of various collagen sorts. Lastly, Vitamin C deficiency is a dietary deficiency which ends up in altered hydroxylase enzyme perform which requires Vitamin C as a cofactor. Osteogenesis imperfecta which is an autosomal dominant dysfunction of sort 1 collagen, which might current with a spectrum of findings from gentle to deadly.
Mobile
Collagen Fibril Meeting
Operate
Collagen is probably the most considerable protein within the human physique. Due to this fact, it may be divided into many sorts. The most typical varieties of collagen are sorts I by V every serving completely different features.