Significance: Using nutraceuticals corresponding to collagen for skincare has been rising, however laws are missing on high quality, absorption, and efficacy. To handle this information hole, scientific research relating to the potential results of collagen-based dietary dietary supplements on pores and skin are being accomplished. Goal: To evaluate the literature and assess accessible randomized-controlled trials utilizing collagen supplementation for remedy efficacy relating to pores and skin high quality, anti-aging advantages, and potential utility in medical dermatology. Proof Overview: A literature search was performed with PubMed utilizing search standards (collagen) AND (complement OR meals OR diet). No decrease restrict on the yr of publication was set. Inclusion standards had been: randomized, placebo-controlled trials utilizing collagen supplementation in human topics associated to dermatology and written in English. Findings: Eleven research with a complete of 805 sufferers had been included for evaluate. Eight research used collagen hydrolysate, 2.5g/d to 10g/d, for 8 to 24 weeks, for the remedy of strain ulcers, xerosis, pores and skin growing older, and cellulite. Two research used collagen tripeptide, 3g/d for 4 to 12 weeks, with notable enchancment in pores and skin elasticity and hydration. Lastly, one research utilizing collagen dipeptide steered anti-aging efficacy is proportionate to collagen dipeptide content material. Conclusions and Relevance: Preliminary outcomes are promising for the quick and long-term use of oral collagen dietary supplements for wound therapeutic and pores and skin growing older. Oral collagen dietary supplements additionally improve pores and skin elasticity, hydration, and dermal collagen density. Collagen supplementation is mostly secure with no reported opposed occasions. Additional research are wanted to elucidate medical use in pores and skin barrier illnesses corresponding to atopic dermatitis and to find out optimum dosing regimens. J Medication Dermatol. 2019;18(1):9-16.
