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MATERIALS AND METHODS
RESULTS AND DISCUSSION
Our outcomes counsel that kind III collagen regulates the diameter of kind I collagen fibrils, which serves as a mechanism to fulfill the physiological necessities of various tissues or of a tissue at completely different developmental phases. Underneath physiological situations, kind III collagen just isn’t solely a vital part of fibrils in tissues such because the media of aorta but in addition an necessary regulatory aspect in kind I collagen fibrillogenesis. The phenotype of kind III collagen poor mice carefully resembles the medical manifestations of Ehlers–Danlos syndrome kind IV sufferers in whom demise outcomes from blood vessel or intestinal rupture (20).
Acknowledgments
We thank Jessie Dausman and Ruth Curry for technical help. This analysis was supported by Nationwide Institutes of Well being Grants R35-CA44339 to R.J. and AR-3564 to S.Okay. X.L. was supported by a fellowship from the Leukemia Society.