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Since 2014, >50 cases of sensory neuronal pain due to vitamin B6 supplementation were reported. In the present study, the neurotoxicity of the different forms of vitamin B6 is tested on SHSY5Y and CaCo-2 cells. Pyridoxine induced cell death in a concentration-dependent way in SHSY5Y cells.
The other vitamers did not affect cell viability. Moreover, both pyridoxal-5-phosphate dependent enzymes were inhibited by pyridoxine. In conclusion, the present study indicates that the neuropathy observed after taking a relatively high dose of vitamin B6 supplements is due to pyridoxine.
The inactive form pyridoxine competitively inhibits the active pyridoxal-5′-phosphate. Consequently, symptoms of vitamin B6 supplementation are similar to those of vitamin B6 deficienc.
P-5-P 100Mg With Zinc – Active Vitamin B6 – 90 Capsules
Ve coenzyme form of vitamin B6
Vitamin B6 is essential for the human body.
It´s part of over 100 enzymatic reactions, the amino acid and protein metabolism in particular.
What Is P-5-P?
This means our body can immediately use it without transforming it first. Vitamin B6 in the form of pyridoxine has to be metabolised to pyridoxal-5-phosphate to be fully effective.
Why you should choose the P-5-P capsules by Fairvital
This product combines P-5-P with zinc, because this trace element is part of the vitamin B6 metabolism.
What Is Pyridoxal-5-Phosphate?
So P5P is the active night form of Vitamin B6. P5p plays an important role in various functions in the body such as metabolism at the cellular level, muscle growth and repair, mood regulation, sleep regulation, and other executive functions.
When P5P is taken in its purest form, it doesn’t have to go through the conversion process in the liver, meaning it’s possible people can then get more benefit out of the nutrient, especially when used with magnesium.