Why Is Reducing Uric Acid In The Blood Good For Gout?
Does Vitamin C Reduce Uric Acid?
A study of almost 47,000 men over a 20-year period found that those taking a vitamin C supplement had a 44 percent lower gout risk. Hyperuricemia is a condition where there’s too much uric acid in your body. Purines are present in your body and found in the foods you eat.
People with gout may experience painful flares (times when the symptoms worsen) and remission (periods when there are virtually no symptoms). At present, there’s no cure for gout, but it can be treated with self-management strategies and medication.
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Possibly, researchers say, but results of studies on vitamin C and gout are mixed. In a 2009 study published in the Archives of Internal Medicine, Hyon K. Choi, MD, of the Boston University School of Medicine, showed that the more vitamin C men took, the less likely they were to get gout. During the 20 years that researchers studied nearly 47,000 men, 1,317 of them developed gout.
For every 500-milligram increase in vitamin C intake, the risk for gout fell by 17 percent. The risk dropped by 45 percent when study participants took more than 1,500 mg of vitamin C a day. In a 2013 study published Arthritis & Rheumatism, a modest vitamin C dose failed to reduce uric acid levels to a clinically significant degree in patients with established gout.
Of the 40 participants with gout, 20 patients already taking allopurinol, a drug that helps the kidney excrete uric acid, were given an additional 500-mg dose of vitamin C daily or had the dose of allopurinol increased. The study found that reduction of uric acid was significantly less in gout patients taking vitamin C compared to those who started or increased their dose of allopurinol. The effect of vitamin C among people with gout needs further study, says Dr. Neogi, who was not involved with the study.
Nd gout are commonly diagnosed in subjects with abnormal purine metabolism. Additionally, there was no significant effect on the serum creatinine level or on the GFR in both study groups. In conclusion, 500 mg vitamin C oral daily dosing might be of the therapeutic value in lowering UA levels in hyperuricemic patient.