In this article we will be discussing a very common question: vitamin k2 menaquinone 4.
Abstract
Mk-7, however significantly increases serum MK-7 levels and therefore may be of particular importance for extrahepatic tissues. Therefore, two vitamin K 2 homologues, menaquinone-4 (MK-4) and menaquinone-7 (MK-7), have been used as nutrients by the food industry and as nutritional supplements to support bone and cardiovascular health. To investigate MK-4 and MK-7 bioavailability, nutritional doses were administered to healthy Japanese women.
Introduction
Osteocalcin, a bone-specific protein synthesized by osteoblasts, and matrix Gla protein synthesized in blood vessel and bone are Gla-containing proteins synthesized at extra-hepatic sites [1]. There are two naturally occurring forms of vitamin K: vitamin K 1 (phylloquinone) derived from green plants and vitamin K 2 (menaquinones, MK-n), which is a series of vitamers with multi-isoprene units at position 3 of the common 2-methyl-1,4-naphthoquinone ring structure. In food, vitamin K 1 is bound to the chloroplast membrane of leafy green vegetables.
Mk-7, MK-8, and MK-9) are found in fermented foods such as cheese, curd, and sauerkraut [2]. The effects of long chain MK-n such as MK-7 on normal blood coagulation is greater and longer lasting than vitamin K 1 and MK-4 [3-5].
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In K accompany high concentrations of undercarboxylated osteocalcin (ucOC) and osteoporotic fractures.
A nine-week, open-labeled, prospective cohort study was conducted in 29 postmenopausal women who suffered hip or vertebral compression fractures. Bisphosphonates) correlated with improvement in %ucOC. Mk-4 supplementation resulted in borderline increases in γ-carboxylated osteocalcin (glaOC; p = 0.07).
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The vitamin K1 and vitamin Menaquinone-4 contents are 200 mg/1,000 g, and the diet is provided in pellet form. For fat amount measurement, the epididymal fat, perirenal fat, and retroperitoneal fat are extracted from dead animal subjects, are washed with 0.9% NaCl, dried by filter paper, and then are weighed[2]. Mce has not independently confirmed the accuracy of these methods.
They are for reference onl.