Medically reviewed by Medicine.com. Final up to date on Feb 1, 2021.
Indications and Utilization for Multi Vitamin Infusion M.V.I. Grownup
M.V.I. Grownup™ is a mixture of nutritional vitamins indicated for the prevention of vitamin deficiency in adults and pediatric sufferers aged 11 years and above receiving parenteral diet.
The doctor mustn’t await the event of scientific indicators of vitamin deficiency earlier than initiating vitamin remedy.
Multi Vitamin Infusion M.V.I. Grownup Dosage and Administration
Essential Dosage and Administration Directions
M.V.I. Grownup is a mixture product that comprises the next nutritional vitamins: ascorbic acid, vitamin A, vitamin D, thiamine, riboflavin, pyridoxine, niacinamide, dexpanthenol, vitamin E, vitamin Okay, folic acid, biotin, and vitamin B12.
M.V.I. Grownup is equipped as a single dose or as a pharmacy bulk bundle for intravenous use meant for administration by intravenous infusion after dilution:
Don’t administer M.V.I. Grownup as a direct, undiluted intravenous injection as it might trigger dizziness, faintness, and tissue irritation.
Dosage Info
The beneficial each day dosage quantity is 10 mL. One each day dose (10 mL) is diluted by including on to a specified quantity of an intravenous fluid [see Dosage and Administration (2.3)].
Sufferers with a number of vitamin deficiencies or with elevated vitamin necessities might have a number of each day dosages as indicated or further doses of particular person nutritional vitamins.
Preparation and Administration Directions
M.V.I. Grownup equipped as a single dose:
M.V.I. Grownup equipped as a pharmacy bulk bundle:
Monitoring Vitamin Blood Ranges
Blood vitamin concentrations needs to be monitored to make sure upkeep of enough ranges, notably in sufferers receiving parenteral multivitamins as the one supply of nutritional vitamins for lengthy durations of time.
Drug Incompatibilities
Dosage Kinds and Strengths
M.V.I. Grownup is an injection accessible as a:
See Description part for vitamin strengths [see Description (11)].
Contraindications
M.V.I. Grownup is contraindicated in sufferers who’ve:
Warnings and Precautions – “multivitamins injection”
Decreased Anticoagulant Impact of Warfarin
M.V.I. Grownup comprises Vitamin Okay which can lower the anticoagulant impact of warfarin. In sufferers who’re on warfarin anticoagulant remedy receiving M.V.I. Grownup, prothrombin time/INR needs to be periodically monitored to find out if the dose of warfarin must be adjusted.
Aluminum Toxicity
M.V.I. Grownup comprises aluminum which may be poisonous. Aluminum might attain poisonous ranges with extended parenteral administration in sufferers with renal impairment. Untimely neonates are notably in danger as a result of their kidneys are immature, they usually require giant quantities of calcium and phosphate options, which comprise aluminum.
Sufferers with impaired kidney perform, together with untimely neonates, who obtain parenteral ranges of aluminum at larger than 4 to five micrograms per kg per day, accumulate aluminum at ranges related to central nervous system and bone toxicity. Tissue loading might happen at even decrease charges of administration. To forestall aluminum toxicity monitor periodically aluminum ranges with extended parenteral administration of M.V.I. Grownup.
Threat of Low Vitamin A Ranges
Vitamin A might adhere to plastic, leading to decrease vitamin A concentrations after administration of M.V.I. Grownup. Subsequently, blood vitamin concentrations needs to be periodically monitored and the administration of further therapeutic doses of Vitamin A could also be required.
Allergic Reactions to Thiamine
Allergic reactions akin to urticaria, periorbital and digital edema, have been reported following intravenous administration of thiamine, which is present in M.V.I. Grownup. There have been uncommon studies of anaphylaxis following intravenous doses of thiamine. No deadly anaphylaxis reactions related to M.V.I. Grownup have been reported.
Hypervitaminosis A
Hypervitaminosis A, manifested by nausea, vomiting, headache, dizziness, blurred imaginative and prescient, has been reported in sufferers with renal failure receiving 1.5 mg/day retinol and in sufferers with liver illness. Subsequently, supplementation of renal failure sufferers and sufferers with liver illnesses with vitamin A, an ingredient present in M.V.I. Grownup, needs to be undertaken with warning [see Use in Specific Populations (8.6, 8.7)]. Blood ranges of Vitamin A needs to be monitored periodically.
Interference with Prognosis of Megaloblastic Anemia
M.V.I. Grownup comprises folic acid and cyanocobalamin which may masks serum deficits of folic acid and cyanocobalamin in sufferers with megaloblastic anemia. Keep away from using M.V.I. Grownup in sufferers with suspected or identified megaloblastic anemia previous to blood sampling for the detection of the folic acid and cyanocobalamin deficiencies.
Potential to Develop Vitamin Deficiencies or Excesses
In sufferers receiving parenteral multivitamins, akin to with M.V.I. Grownup, blood vitamin concentrations needs to be periodically monitored to find out if vitamin deficiencies or excesses are growing. M.V.I. Grownup might not right long-standing particular vitamin deficiencies. The administration of further doses of particular nutritional vitamins could also be required [see Dosage and Administration (2.2)].
Interference with Urine Glucose Testing
M.V.I. Grownup comprises Vitamin C which is often known as ascorbic acid. Ascorbic acid within the urine might trigger false destructive urine glucose determinations.
Opposed Reactions
The next opposed reactions are mentioned in larger element in different part of the labeling.
The next opposed reactions have been recognized throughout put up approval use of M.V.I. Grownup. As a result of these reactions are reported voluntarily from a inhabitants of unsure dimension, it’s not at all times potential to reliably estimate their frequency or set up a causal relationship to drug publicity.
Dermatologic: rash, erythema, pruritus
CNS: headache, dizziness, agitation, nervousness
Ophthalmic: diplopia
Drug Interactions
Impact of M.V.I. Grownup on Different Medicine
Phenytoin: Folic acid might enhance phenytoin metabolism and decrease the serum focus of phenytoin leading to elevated seizure exercise.
Methotrexate: Folic acid might lower a affected person’s response to methotrexate remedy.
Levodopa: Pyridoxine might enhance the metabolism of levodopa (lower blood stage of levodopa) and reduce its efficacy.
Antibiotics: Thiamine, riboflavin, pyridoxine, niacinamide, and ascorbic acid lower antibiotic actions of erythromycin, kanamycin, streptomycin, doxycycline, and lincomycin.
Bleomycin: Ascorbic acid and riboflavin inactivate bleomycin in vitro, thus the exercise of bleomycin could also be decreased.
Impact of Different Medicine on M.V.I. Grownup
Hydralazine or Isoniazid:
Concomitant administration of hydralazine or isoniazid might enhance pyridoxine necessities.
Phenytoin:
Phenytoin might lower serum folic acid concentrations.