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Vitamin B6 Keppra Irritability

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Epilepsy & Behavior Reports

Racetam, a commonly prescribed antiseizure medication (ASM), may cause irritability, depression, and anger. Mitigation strategies are limited, including discontinuation, supplementation with vitamin B6, or switching to an alternative ASM. The objective of this project was to describe our preliminarily experience with vitamin B6 supplementation for alleviating levetiracetam-associated irritability in male Veterans with epilepsy.
Methods Retrospective chart reviews were completed for patients who had an active prescription for levetiracetam from the William S. Middleton Memorial Veterans Hospital from January 1, 2015 to June 1, 2020. A total of 26 charts were screened. Results Of 22 patients, data was available for 20 (91%).

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Only prescribed antiseizure medication (ASM), may cause irritability, depression, and anger. Several retrospective studies and anecdotal reports, primarily in pediatric populations, suggest vitamin B6 supplementation may be helpful in reducing levetiracetam-associated irritability. Although data in adult patients is limited, and no data is available for Veterans.
Methods: Retrospective chart reviews were completed for patients who had an active prescription for levetiracetam from the William S. Middleton Memorial Veterans Hospital from January 1, 2015 to June 1, 2020. A total of 26 charts were screened. These symptoms and scores were then compared pre- and post-B6 supplementation.
Results: Of 22 patients, data was available for 20 (91%). For patients with data available, 9 (45%) showed improved irritability following supplementation with vitamin B6 and 11 (55%) showed no improvement.

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Ts related to the use of levetiracetam (LEV) in epilepsy are increasingly being recognized.
Patients followed in our center have reported improvement of these side effects after starting pyridoxine (vitamin B 6 ) supplements. Using mailed questionnaires, retrospective chart reviews, and phone call follow-ups, we analyzed 42 pediatric patients who had been treated with LEV and pyridoxine. The effects of pyridoxine supplementation were observed during the first week.
Pyridoxine is an easily available, inexpensive, and safe therapeutic option. Given these preliminary results, we plan to conduct a placebo-controlled cross-over study to better characterize these observation.

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Epilepsy.Com

On Lamictal for 3 weeks and my doctor just added Keppra.
I have heard that Keppra has mood swing and aggressive behavior as side effects.

Does Someone Know If The Likelihood Of Having Those 2 Side Effects Is Very High Or They Are Side Effects That Majority Of People Never Have Them?

It is also said that Vitamin B6 can reduce those side effects.

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