Vitamin B6 Mechanism Of Action

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The 4-methanol form of vitamin B6, an important water-soluble vitamin that is naturally present in many foods. As its classification as a vitamin implies, Vitamin B6 (and pyridoxine) are essential nutrients required for normal functioning of many biological systems within the body. More specifically, pyridoxine is converted to pyridoxal 5-phosphate in the body, which is an important coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid.
Vitamin B6, principally in its biologically active coenzyme form pyridoxal 5′-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA) 2. Pyridoxine is used medically for the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy (due to Isoniazid’s mechanism of action which competitively inhibits the action of pyridoxine in the above-mentioned metabolic functions).

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Ess antiemetic effects since 1942.
This water soluble compound has several forms in the circulation including pyridoxine, pyridoxal, and pyridoxal phosphate. With Diclectin® exhibiting a significant antiemetic effect in pregnancy, serum concentrations of pyridoxine were unmeasurable in almost all patients and those of pyridoxal were undetectable in half of patients. Our data suggest that there is a correlation between PLP levels and PUQE score of morning sickness symptoms when pyridoxine and pyridoxal levels are undetectable, and hence they might be prodrugs of PLP, which may be the active antiemetic form of vitamin B.

Side Effects

Min by mouth with or without food, usually once daily. If you are taking the extended-release capsules, swallow them whole. Doing so can release all of the drug at once, increasing the risk of side effects.
Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. If you are using the liquid form of this product, carefully measure the dose using a special measuring device/spoon.
Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the container well before each use. Do not prepare a supply for future use.
To help you remember, take it at the same time each day.

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All three compounds are converted to pyridoxal-5′-phosphate (PLP), an important cofactor for glucose, lipids, and amino acid metabolism as well as neurotransmitter synthesis. It eventually became clear that the symptomatic infants were fed a commercial formula that contained approximately one-third the vitamin B 6 found in other infant formulas.
Even with better awareness of the problem, sporadic cases of infantile seizures from dietary vitamin B 6 deficiency still occur, most commonly as a result of breastfeeding by malnourished mothers from poor socioeconomic backgrounds or in underdeveloped countries. The typical patients have a normal birth history and are entirely healthy until the development of hyperirritability and an exaggerated auditory startle. Recurrent convulsions often occur abruptly, as may status epilepticus.
Once the dietary insufficiency is corrected, patients become free of seizures and develop normally. Another rare form of pyridoxine-responsive seizure occurs in infants with inborn errors in PLP metabolism. The current list includes ALDH7A1, ALDH4A1, PNPO, TNSALP, PLPBP, and PLPHP, and will likely continue to expand with advances in our understanding of this group of diseases (Johnstone et al., 2019;Pearl and Gospe, 2014;Wilson et al., 2019).
The seizures typically respond poorly to anticonvulsants.

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