Vitamin B6 Overdose

If you’re here, then you probably Google’d: vitamin b6 overdose. This subject along with many others are quite common. We will do our best to answer this and many other similar questions in this article which should ease your mind regarding this subject.

Msd Manual

N of megadoses (> 500 mg/day) of pyridoxine (eg, taken to treat carpal tunnel syndrome or premenstrual syndrome although efficacy is unproved) may cause peripheral neuropathy with deficits in a stocking-glove distribution, including progressive sensory ataxia and severe impairment of position and vibration senses. Senses of touch, temperature, and pain are less affected. Motor and central nervous systems are usually intac.

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Background: B-Complex vitamins are essential for functioning of the nervous system, and supplementation is generally well tolerated. Herein, we report a case of reversible pyridoxine induced sensorimotor neuropathy and disequilibrium in an octogenarian. She had absent deep tendon reflexes in both upper and lower extremities, and a steppage gait on the left.
Additional work-up, including serum B12, hemoglobin A1c, thyroid panel, SPEP/UPEP were unremarkable. Conclusions: In conclusion, sensorimotor neuropathy secondary to pyridoxine toxicity can be debilitating, but is potentially reversible with timely cessation of vitamin B6 supplementation and intensive physiotherapy. Dr. Hosseini has nothing to disclose.

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If your multi contains 2,000% of the Daily Value (DV), which is 2 mg for adults, then your multi has 40 mg of B-6.

Merck Manual

Icity is rare but can result from taking high doses of vitamin B6 supplements. Vitamin B6 in very high doses may be prescribed for such disorders as carpal tunnel syndrome or premenstrual syndrome, although there is little evidence of benefit.
Taking very high doses of vitamin B6 may damage the nerves (called neuropathy Polyneuropathy Polyneuropathy is the simultaneous malfunction of many peripheral nerves throughout the body. People may be unable to tell where their arms and legs are (position sense) and to feel vibrations.

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